NUBP2 Antibody (H-2): sc-376786

NUBP2 Antibody (H-2) is a mouse monoclonal IgG1 antibody that detects NUBP2 in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NUBP2, also known as cytosolic Fe/S cluster assembly factor NUBP2, is a crucial 271 amino acid protein that plays a significant role in the assembly of iron-sulfur (Fe/S) clusters, which are vital for the function of numerous enzymes and proteins within the cell. NUBP2 is predominantly localized in both the nucleus and cytoplasm, with notable presence at centrosomes during mitosis, highlighting NUBP2′s importance in cellular division and function. NUBP2 is essential for the maturation of extramitochondrial Fe/S proteins, facilitating the transfer of a labile 4Fe-4S cluster to various apoproteins, thereby influencing a range of biological processes including cellular respiration and metabolism. NUBP2 is a member of the NUBP/MRP gene subfamily of ATP-binding proteins and is encoded by a gene located on human chromosome 16p13.3 and mouse chromosome 17 A3.3, indicating evolutionary conservation and significance across species. With a wide expression profile, particularly in skeletal muscle, fetal liver, lung, brain, and kidney, anti-NUBP2 antibody (H-2) serves as a valuable tool for researchers investigating the intricate roles of Fe/S proteins in cellular physiology and pathology.

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NUBP2 Antibody (H-2) References:

1. Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA.  |  Kargul, GJ., et al. 2000. Genome Res. 10: 916-23. PMID: 10899141
2. Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA.  |  Sano, Y., et al. 2001. Genome Res. 11: 1833-41. PMID: 11691847
3. Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding domains of P-glycoprotein.  |  Carrier, I., et al. 2003. Biochemistry. 42: 12875-85. PMID: 14596601
4. Nubp1 is required for lung branching morphogenesis and distal progenitor cell survival in mice.  |  Schnatwinkel, C. and Niswander, L. 2012. PLoS One. 7: e44871. PMID: 23028652
5. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.  |  Kypri, E., et al. 2014. Cell Mol Life Sci. 71: 517-38. PMID: 23807208
6. The expression of cuproptosis-related genes in hepatocellular carcinoma and their relationships with prognosis.  |  Zhao, X., et al. 2022. Front Oncol. 12: 992468. PMID: 36313717
7. RNA-Sequencing Analysis Identification of Potential Biomarkers for Diagnosis of Sarcopenia.  |  Furutani, M., et al. 2023. J Gerontol A Biol Sci Med Sci. 78: 1991-1998. PMID: 37347997
8. Serum autoantibody profiling of oral squamous cell carcinoma patients reveals NUBP2 as a potential diagnostic marker.  |  Abdulla, R., et al. 2023. Front Oncol. 13: 1167691. PMID: 37810966
9. Abnormal upregulation of NUBP2 contributes to cancer progression in colorectal cancer.  |  Lan, D., et al. 2025. Mol Cell Biochem. 480: 399-410. PMID: 38492158
10. NUBP2 deficiency disrupts the centrosome-check point in the brain and causes primary microcephaly.  |  Rushforth, R., et al. 2025. medRxiv.. PMID: 39867373

The preferred NUBP2 antibody is NUBP2 Antibody (C-12): sc-376784.