NPE-caged-proton (CAS 1186195-63-0)
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Available in US only.
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NPE-caged-proton is a 1-(2-nitrophenyl)ethyl caged proton that releases a sulfate ion and a proton upon photolysis. This generates rapid acidifications down to pH 2 (pH jumps). NPE-caged-proton is a caged proton composed of a nitrogen-containing polyethylene glycol (PEG) cage that encapsulates a proton. The proton is securely held within the cage through a hydrogen bond formed between the nitrogen atom and the proton. When NPE-caged-proton encounters a proton acceptor, such as a protein or enzyme, it undergoes a process where the proton is released from the cage. Subsequently, the liberated proton can engage with the target molecule, leading to alterations in its structure and/or function. In vitro, NPE-caged-proton is used to study the effect of proton transfer on biological systems, such as proteins and enzymes.
NPE-caged-proton (CAS 1186195-63-0) References
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- Protons act as a transmitter for muscle contraction in C. elegans. | Beg, AA., et al. 2008. Cell. 132: 149-60. PMID: 18191228
- A proton current drives action potentials in genetically identified sour taste cells. | Chang, RB., et al. 2010. Proc Natl Acad Sci U S A. 107: 22320-5. PMID: 21098668
- Biased Brownian stepping rotation of FoF1-ATP synthase driven by proton motive force. | Watanabe, R., et al. 2013. Nat Commun. 4: 1631. PMID: 23535652
- Gating Currents in the Hv1 Proton Channel. | De La Rosa, V. and Ramsey, IS. 2018. Biophys J. 114: 2844-2854. PMID: 29925021
- Voltage and pH difference across the membrane control the S4 voltage-sensor motion of the Hv1 proton channel. | Schladt, TM. and Berger, TK. 2020. Sci Rep. 10: 21293. PMID: 33277511
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NPE-caged-proton, 1 mg | sc-361277A | 1 mg | $162.00 | |||
| US: Only available in the US | ||||||
NPE-caged-proton, 5 mg | sc-361277 | 5 mg | $318.00 | |||
| US: Only available in the US | ||||||