NPDC-1 Antibody (16E4): sc-65387

NPDC-1 Antibody (16E4) is a mouse monoclonal IgG1 antibody that detects NPDC-1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-NPDC-1 antibody (16E4) is available as the non-conjugated format. NPDC-1, or Neural Proliferation Differentiation and Control-1, plays a crucial role in the regulation of neuronal differentiation, being expressed in neurons that have ceased dividing and are transitioning into a differentiated state. NPDC-1 is primarily located in the cytoplasm, where NPDC-1 is transported from the Golgi apparatus via vesicles and subsequently internalized by endosomes at the cell membrane, a process vital for function in neuronal signaling and development. Proper localization of NPDC-1 is essential for interactions with key proteins such as cyclin-dependent kinase 2 (Cdk2), D-type cyclins, and the transcription factor E2F1, which collectively influence cell cycle regulation and apoptosis. NPDC-1 has been shown to colocalize with synaptic vesicle proteins, including synaptophysin, synaptobrevin 2, and Rab3 GTP/GDP exchange protein, highlighting importance in synaptic function and neural communication. The amino acid sequence of NPDC-1 is highly conserved across species, including mouse, rat, and human, underscoring fundamental role in neuronal biology.

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NPDC-1 Antibody (16E4) References:

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