Molecular structure of Nocardamine, CAS Number: 26605-16-3
Nocardamine (CAS 26605-16-3)
Alternate Names:
deferrioxamine E
Application:
Nocardamine is a cyclic siderophore
CAS Number:
26605-16-3
Purity:
≥95%
Molecular Weight:
600.70
Molecular Formula:
C27H48N6O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nocardamine is a cyclic siderophore. Siderophores are specialized molecules synthesized by bacteria and fungi to scavenge iron from their environment, a critical function given the essential role of iron in biological processes and its relative scarcity in many microbial habitats. Nocardamine, like other siderophores, binds to iron with high affinity, facilitating its uptake by the microbial cells through specific receptor-mediated transport mechanisms. Stimulates secondary metabolite formation and morphological differentiation in various actinomycete strains. Also induces morphological changes in insect cells.
Nocardamine (CAS 26605-16-3) References
- Cyclic peptides of the nocardamine class from a marine-derived bacterium of the genus Streptomyces. | Lee, HS., et al. 2005. J Nat Prod. 68: 623-5. PMID: 15844966
- Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activity. | Kalinovskaya, NI., et al. 2011. Microbiol Res. 166: 654-61. PMID: 21376551
- Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2. | Shaaban, KA., et al. 2014. J Antibiot (Tokyo). 67: 223-30. PMID: 24252813
- Morphological Changes in Insect BM-N4 Cells Induced by Nocardamine. | Matsubara, K., et al. 1998. Biosci Biotechnol Biochem. 62: 2049-51. PMID: 27385455
- nonG, a constituent of the nonactin biosynthetic gene cluster, regulates nocardamine synthesis in Streptomyces albus J1074. | Park, W., et al. 2017. Biochem Biophys Res Commun. 490: 664-669. PMID: 28634080
- Genome Sequencing of Streptomyces atratus SCSIOZH16 and Activation Production of Nocardamine via Metabolic Engineering. | Li, Y., et al. 2018. Front Microbiol. 9: 1269. PMID: 29963027
- Osmanicin, a Polyketide Alkaloid Isolated from Streptomyces osmaniensis CA-244599 Inhibits Elastase in Human Fibroblasts. | Samy, MN., et al. 2019. Molecules. 24: PMID: 31208056
- Novel South African Rare Actinomycete Kribbella speibonae Strain SK5: A Prolific Producer of Hydroxamate Siderophores Including New Dehydroxylated Congeners. | Acquah, KS., et al. 2020. Molecules. 25: PMID: 32610457
- Nocardamine-Dependent Iron Uptake in Pseudomonas aeruginosa: Exclusive Involvement of the FoxA Outer Membrane Transporter. | Normant, V., et al. 2020. ACS Chem Biol. 15: 2741-2751. PMID: 32902248
- Characterization of Actinomycetes Strains Isolated from the Intestinal Tract and Feces of the Larvae of the Longhorn Beetle Cerambyx welensii. | Santamaría, RI., et al. 2020. Microorganisms. 8: PMID: 33339339
- Aromatic Polyketides and Hydroxamate Siderophores from a Marine-Algae-Derived Streptomyces Species. | Xia, K., et al. 2021. J Nat Prod. 84: 1550-1555. PMID: 33983744
- Bioactivities and Mode of Actions of Dibutyl Phthalates and Nocardamine from Streptomyces sp. H11809. | Mahmud, F., et al. 2022. Molecules. 27: PMID: 35408690
- Detection of tetracyclines and efflux pump inhibitors. | Rothstein, DM., et al. 1993. Antimicrob Agents Chemother. 37: 1624-9. PMID: 8215274
Activator of:
FAM96A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nocardamine, 1 mg | sc-281105 | 1 mg | $245.00 | |||
Nocardamine, 5 mg | sc-281105A | 5 mg | $612.00 |