Nitisinone CAS: 104206-65-7
MF: C14H10F3NO5
MW: 329.23
An herbicidil triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD).

Nitisinone (CAS 104206-65-7)

Nitisinone | CAS 104206-65-7 is rated 5.0 out of 5 by 1.
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Synonym: 2-(2-Nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione; 2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
Application: An herbicidil triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD)
CAS Number: 104206-65-7
Purity: ≥97%
Molecular Weight: 329.23
Molecular Formula: C14H10F3NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nitisinone is a herbicidal triketone that inhibits HPPD (4-hydroxyphenylpyruvate dioxygenase), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.


References

Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),

Physical State :
Solid
Solubility :
Soluble in Chloroform
Storage :
Store at -20° C
Melting Point :
129-131°C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
115355
SMILES :
C1CC(=O)C(C(=O)C1)C(=O)C2=C(C=C(C=C2)C(F)(F)F)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Keenan et al Keenan et al. (PubMed ID 25940034) found that nitisinone prevented deposition of ochronotic pigment in mice with alkaptonuria. -SCBT Publication Review
Date published: 2015-05-22
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