Nifurtimox CAS: 23256-30-6
MF: C10H13N3O5S
MW: 287.29
A nitrofuran antiprotazoal.

Nifurtimox (CAS 23256-30-6)

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Application: Nifurtimox is a nitrofuran antiprotazoal
CAS Number: 23256-30-6
Molecular Weight: 287.29
Molecular Formula: C10H13N3O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Nifurtimox is a nitrofurane derivative antiprotozoal that shows anti Trypanosoma cruzi activity through bioreduction of the nitro-group and dependence on redox cycling with O2. When used in combination with Buthionine Sulfoximine (sc-200824), Nifurtimox has displayed increased toxicity toward the epimastigote, trypomastigote, and amastigote forms of Trypanosoma cruzi. In the mammary tissue of female Sprague-Dawley rats Nifurtimox was observed, in a purine dependent manner, to biotransform to xanthine-oxioreductase in the cytosol. This activity can be inhibited by Allopurinol (sc-207272). The compound has also gone under the same transformation in the presence of NADPH and inhibited partially by Diphenyleneiodonium chloride (sc-202584) and completely by carbon monoxide.


References

1. Letelier, M.E., et al. 1990. Exp. Parasitol. 71: 357-363. PMID: 2121515
2. Faundez, M., et al. 2005. Antimicrob. Agents Chemother. 49: 126-130. PMID: 15616285
3. Bartel, L.C., et al. 2010. Hum Exp Toxicol. 29: 813-822. PMID: 20150355

Physical State :
Solid
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6842999
SMILES :
CC1CS(=O)(=O)CCN1N=CC2=CC=C(O2)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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