Nidulin (CAS 10089-10-8)
QUICK LINKS
Nidulin is a depsidone produced by several fungal species with potent and selective antibacterial activity.While literature relating to nidulin is limited, it is closely related to folipastatin and unguinol identified as inhibitors of phospholipase A2, arachidonic acid release from rat polymorphonuclear leukocytes and nitrendipine binding to porcine heart membrane. While showing some calcium blocking attributes these metabolites have potential as anti-inflammatory agents. It effectively targets M. tuberculosis, M. ranoe, T. tonsurans, and M. audouini. It demonstrates inhibitory effects on methicillin-resistant S. aureus (MRSA) growth (MIC = 4 µg/ml) and shows larvicidal activity against Artemia (LC50 = 2.8 µg/ml). Nidulin displays cytotoxicity towards MOLT-3 cells (IC50 = 21.2 µM) while being non-toxic to HuCCA-1, HepG2, and A549 cells (IC50s = >112.7 µM). It inhibits aromatase with an IC50 value of 11.2 µM. Nidulin, a depsidone derived from A. nidulans, possesses a wide range of antimicrobial properties.
Nidulin (CAS 10089-10-8) References
- Nidulin and ustin; two chlorine-containing metabolic products of Aspergillus nidulans. | DEAN, FM., et al. 1953. Nature. 172: 344. PMID: 13087222
- Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Taxonomy, fermentation, isolation, structure determination and biological properties. | Hamano, K., et al. 1992. J Antibiot (Tokyo). 45: 1195-201. PMID: 1399838
- [A new antibiotic produced by a strain of Sterygmatocystis nidulans, nidulin]. | ARQUIE, E. and GRUMBACH, F. 1949. C R Hebd Seances Acad Sci. 229: 602-4. PMID: 15395336
- Depsidones, aromatase inhibitors and radical scavenging agents from the marine-derived fungus Aspergillus unguis CRI282-03. | Sureram, S., et al. 2012. Planta Med. 78: 582-8. PMID: 22307935
- Depsidone Derivatives and a Cyclopeptide Produced by Marine Fungus Aspergillus unguis under Chemical Induction and by Its Plasma Induced Mutant. | Yang, WC., et al. 2018. Molecules. 23: PMID: 30177651
- Semisynthesis and antibacterial activities of nidulin derivatives. | Isaka, M., et al. 2019. J Antibiot (Tokyo). 72: 181-184. PMID: 30555155
- Studies on fungal products. XVI. New metabolites related to 3-methylorsellinate from Aspergillus silvaticus. | Kawahara, N., et al. 1988. Chem Pharm Bull (Tokyo). 36: 398-400. PMID: 3378300
- Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections. | Nguyen, HT., et al. 2021. Antibiotics (Basel). 10: PMID: 34208698
- Secondary Metabolite Variation and Bioactivities of Two Marine Aspergillus Strains in Static Co-Culture Investigated by Molecular Network Analysis and Multiple Database Mining Based on LC-PDA-MS/MS. | Wang, Y., et al. 2022. Antibiotics (Basel). 11: PMID: 35453264
- Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored. | Domingos, LTS., et al. 2022. Biomolecules. 12: PMID: 36551248
- The biosynthesis of nidulin and trisdechloronornidulin. | Sierankiewicz, J. and Gatenbeck, S. 1973. Acta Chem Scand. 27: 2710-6. PMID: 4591514
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nidulin, 1 mg | sc-202244 | 1 mg | $408.00 |