NFS1 Antibody (2635E1a): sc-81107
- NFS1 Antibody (2635E1a) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the N-terminus of NFS1 of human origin
- recommended for detection of NFS1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NFS1 Antibody (2635E1a). This work is in progress.
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NFS1 Antibody (2635E1a) is a mouse monoclonal IgG1 antibody that detects NFS1 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). NFS1, also known as nitrogen fixation 1 or IscS, plays a crucial role in cellular metabolism by catalyzing the removal of sulfur from cysteine to produce alanine, which is essential for the synthesis of iron-sulfur (Fe-S) clusters. These clusters are vital cofactors involved in numerous biological processes, including electron transfer in oxidative phosphorylation and enzymatic reactions in key metabolic pathways. The proper functioning of NFS1 is particularly important in tissues with high metabolic demands, such as heart and skeletal muscle, where NFS1 expression is most abundant. Additionally, NFS1′s localization in the cytoplasm and mitochondrion is significant, as NFS1 allows for the efficient supply of inorganic sulfur necessary for the assembly of Fe-S clusters, thereby supporting the structural integrity and activity of various enzymes, including those involved in DNA repair. NFS1 (2635E1a) antibody is an invaluable tool for researchers studying the intricate roles of sulfur metabolism and Fe-S cluster biogenesis in human health and disease.
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NFS1 Antibody (2635E1a) References:
- Nfs1 cysteine desulfurase protein complexes and phosphorylation sites as assessed by mass spectrometry. | Rocha, AG., et al. 2017. Data Brief. 15: 775-799. PMID: 29159215
- NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. | Alvarez, SW., et al. 2017. Nature. 551: 639-643. PMID: 29168506
- A recurring NFS1 pathogenic variant causes a mitochondrial disorder with variable intra-familial patient outcomes. | Hershkovitz, T., et al. 2021. Mol Genet Metab Rep. 26: 100699. PMID: 33457206
- Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors. | Chafe, SC., et al. 2021. Sci Adv. 7: PMID: 34452919
- Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis. | Lin, JF., et al. 2022. Signal Transduct Target Ther. 7: 54. PMID: 35221331
- Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction. | Fujihara, KM., et al. 2022. Sci Adv. 8: eabm9427. PMID: 36103522
- Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity. | Wang, Y., et al. 2023. Cell Signal. 107: 110655. PMID: 36924813
- Resveratrol drives ferroptosis of acute myeloid leukemia cells through Hsa-miR-335-5p/NFS1/ GPX4 pathway in a ROS-dependent manner. | Liu, J., et al. 2023. Cell Mol Biol (Noisy-le-grand). 69: 131-137. PMID: 37715395
- NFS1 as a Candidate Prognostic Biomarker for Gastric Cancer Correlated with Immune Infiltrates. | Jiang, Y., et al. 2024. Int J Gen Med. 17: 3855-3868. PMID: 39253726
- NFS1 inhibits ferroptosis in gastric cancer by regulating the STAT3 pathway. | Jiang, Y., et al. 2024. J Bioenerg Biomembr. 56: 573-587. PMID: 39254861
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFS1 Antibody (2635E1a) | sc-81107 | 100 µg/ml | $339.00 |