Neurogenin 1 Antibody (OR-7): sc-100332

Neurogenin 1 Antibody (OR-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Neurogenin 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Neurogenin 1 antibody (OR-7) is available as a non-conjugated format. The Neurogenin family, which includes Neurogenin 1, Neurogenin 2, and Neurogenin 3, is part of the basic helix-loop-helix (bHLH) superfamily, known for its role as transcriptional regulators that influence cell fate decisions. Neurogenin 1 is particularly crucial during neurogenesis, where Neurogenin 1 is expressed in specific progenitor populations within the central and peripheral nervous systems. Neurogenin 1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia, highlighting Neurogenin 1′s importance in the development of sensory neurons. The gene encoding Neurogenin 1 is located on human chromosome 5q23-q31, and proper Neurogenin 1 function is vital for the formation of the nervous system, making Neurogenin 1 a key target for studies related to neurodevelopmental disorders and regenerative medicine.

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Neurogenin 1 Antibody (OR-7) References:

1. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.  |  Gradwohl, G., et al. 2000. Proc Natl Acad Sci U S A. 97: 1607-11. PMID: 10677506
2. Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3.  |  Huang, HP., et al. 2000. Mol Cell Biol. 20: 3292-307. PMID: 10757813
3. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.  |  Jacquemin, P., et al. 2000. Mol Cell Biol. 20: 4445-54. PMID: 10825208
4. Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.  |  Jensen, J., et al. 2000. Diabetes. 49: 163-76. PMID: 10868931
5. Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.  |  Schwitzgebel, VM., et al. 2000. Development. 127: 3533-42. PMID: 10903178
6. Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation.  |  Ma, Q., et al. 2000. J Assoc Res Otolaryngol. 1: 129-43. PMID: 11545141
7. Proprotein convertase PACE4 is down-regulated by the basic helix-loop-helix transcription factor hASH-1 and MASH-1.  |  Yoshida, I., et al. 2001. Biochem J. 360: 683-9. PMID: 11736660
8. Epigenetic profiling of synchronous colorectal neoplasias by quantitative DNA methylation analysis.  |  Ogino, S., et al. 2006. Mod Pathol. 19: 1083-90. PMID: 16699497
9. Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.  |  Hill, GW., et al. 2012. Stem Cells Dev. 21: 2827-37. PMID: 22512716
10. Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer.  |  Philipp, AB., et al. 2014. BMC Cancer. 14: 245. PMID: 24708595
11. neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia.  |  Ma, Q., et al. 1998. Neuron. 20: 469-82. PMID: 9539122
12. The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons.  |  Fode, C., et al. 1998. Neuron. 20: 483-94. PMID: 9539123

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Neurogenin 1 Antibody (OR-7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Neurogenin 1 Antibody (OR-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Neurogenin 1 Antibody (OR-7) Specifications

Alternate Product Name: Neurogenin 1

Product Clone Name: OR-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 82-164

Epitope Target: Neurogenin 1

Epitope Species: human

Product Reactivity/Detection: Neurogenin 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Neurogenin 1 Antibody (OR-7): N/A