Neuro-2A Whole Cell Lysate: sc-364185

Neuro-2A whole cell lysate is derived from the Neuro-2A cell line, a mouse neuroblastoma cell line. This lysate is widely used in scientific research to study neuronal differentiation, signal transduction, and neurotoxicity. Neuro-2A cells can differentiate into neuron-like cells under specific conditions, making them a valuable model for investigating neuronal development and function. Researchers utilize Neuro-2A whole cell lysate to analyze key signaling pathways involved in neuronal differentiation, such as the Wnt/β-catenin, Notch, and MAPK/ERK pathways. This lysate facilitates the study of protein expression, post-translational modifications, and interactions between signaling molecules essential for neuronal development. Additionally, it is employed to examine the effects of various chemical modulators on these signaling pathways, providing insights into the molecular mechanisms regulating neuronal differentiation and survival. Recent studies have used Neuro-2A whole cell lysate for proteomic and transcriptomic analyses to identify novel proteins and signaling networks involved in neurogenesis and neuronal function. By offering detailed insights into the molecular and cellular mechanisms underlying neuronal differentiation and signal transduction, Neuro-2A whole cell lysate remains a crucial resource for advancing research in neurobiology and understanding the complexities of neuronal signaling.

Neuro-2A Whole Cell Lysate References:

1. Dexamethasone treatment of calves latently infected with bovine herpesvirus 1 leads to activation of the bICP0 early promoter, in part by the cellular transcription factor C/EBP-alpha.  |  Workman, A., et al. 2009. J Virol. 83: 8800-9. PMID: 19553330
2. Bovine herpesvirus 1 productive infection and immediate early transcription unit 1 promoter are stimulated by the synthetic corticosteroid dexamethasone.  |  Kook, I., et al. 2015. Virology. 484: 377-385. PMID: 26226582