Neu5Ac-α-4MU (CAS 76204-02-9)
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Neu5Ac-α-4MU is a synthetically produced compound used in biochemical assays to study sialic acid metabolism and sialidase (neuraminidase) enzyme activity. This compound is employed as a fluorogenic substrate in enzyme assays, where the release of 4-methylumbelliferone upon cleavage by sialidases can be quantified using fluorescence spectroscopy. As such, Neu5Ac-α-4MU is instrumental in characterizing sialidase activity in various biological samples, including bacterial, viral, and mammalian systems. Its use facilitates the screening of sialidase inhibitors and contributes to the understanding of the role of sialic acids in cellular communication, pathogen infection, and immune responses.
Neu5Ac-α-4MU (CAS 76204-02-9) References
- Integration of neuraminidase inhibitor assay into a single-step operation using a combinable poly(dimethylsiloxane) capillary sensor. | Ishimoto, T., et al. 2013. Analyst. 138: 3158-62. PMID: 23571501
- Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-alpha-D-N-acetylneuraminate) substrate. | Potier, M., et al. 1979. Anal Biochem. 94: 287-96. PMID: 464297
- The synthesis of 4-methylumbelliferyl alpha-ketoside of N-acetylneuraminic acid and its use in a fluorometric assay for neuraminidase. | Myers, RW., et al. 1980. Anal Biochem. 101: 166-74. PMID: 6243885
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Neu5Ac-α-4MU, 10 mg | sc-222055 | 10 mg | $210.00 | |||
Neu5Ac-α-4MU, 100 mg | sc-222055A | 100 mg | $300.00 | |||
Neu5Ac-α-4MU, 250 mg | sc-222055B | 250 mg | $750.00 | |||
Neu5Ac-α-4MU, 500 mg | sc-222055C | 500 mg | $1660.00 | |||
Neu5Ac-α-4MU, 1 g | sc-222055D | 1 g | $2800.00 |