Molecular structure of Nemadectin, CAS Number: 102130-84-7
Nemadectin (CAS 102130-84-7)
Application:
Nemadectin is a broad-spectrum endectocidal and nematocidal antibiotic
CAS Number:
102130-84-7
Purity:
>95%
Molecular Weight:
612.80
Molecular Formula:
C36H52O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nemadectin, initially described as LL-F28249-a, is a macrocyclic lactone antibiotic demonstrating broad-spectrum endectocidal and nematocidal activity. It bears structural similarity to the milbemycin and avermectin antibiotics, differing by the unsaturated side-chain extending from the 6,6-spiroketal core of the antibiotic. Nemadectin has demonstrated efficacy against the natural canine-infecting helminths and against ivermectin-resistant Haemonchus contortus in sheep.
Nemadectin (CAS 102130-84-7) References
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- Multiresidue determination of abamectin, doramectin, ivermectin, and moxidectin in milk using liquid chromatography and fluorescence detection. | Schenck, FJ. and Lagman, LH. 1999. J AOAC Int. 82: 1340-4. PMID: 10589486
- Amphidial structure of ivermectin-resistant and susceptible laboratory and field strains of Haemonchus contortus. | Freeman, AS., et al. 2003. Vet Parasitol. 110: 217-26. PMID: 12482650
- Efficacy of moxidectin, nemadectin and ivermectin against an ivermectin-resistant strain of Haemonchus contortus in sheep. | Pankavich, JA., et al. 1992. Vet Rec. 130: 241-2, 243. PMID: 1514227
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- Reversal of P-glycoprotein-mediated multidrug resistance in vitro by doramectin and nemadectin. | Gao, A., et al. 2010. J Pharm Pharmacol. 62: 393-9. PMID: 20487225
- Toxicology of avermectins and milbemycins (macrocylic lactones) and the role of P-glycoprotein in dogs and cats. | Merola, VM. and Eubig, PA. 2012. Vet Clin North Am Small Anim Pract. 42: 313-33, vii. PMID: 22381182
- An overview on chemical derivatization and stability aspects of selected avermectin derivatives. | Awasthi, A., et al. 2012. Chem Pharm Bull (Tokyo). 60: 931-44. PMID: 22863694
- Complete genome sequence of Streptomyces cyaneogriseus ssp. noncyanogenus, the thermotolerant producer of commercial antibiotics nemadectin. | Wang, H., et al. 2015. J Biotechnol. 204: 1-2. PMID: 25842156
- Efficacy of nemadectin, a new broad-spectrum endectocide, against natural infections of canine gastrointestinal helminths. | Doscher, ME., et al. 1989. Vet Parasitol. 34: 255-9. PMID: 2617829
- Silica based click-dibenzo-18-crown-6-ether high performance liquid chromatography stationary phase and its application in separation of fullerenes. | Li, Y., et al. 2018. Talanta. 178: 195-201. PMID: 29136812
- Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms. | Kim, JH., et al. 2018. Proc Natl Acad Sci U S A. 115: 6828-6833. PMID: 29903901
- Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis. | Jin, P., et al. 2020. Synth Syst Biotechnol. 5: 214-221. PMID: 32695892
- LL-F28249 antibiotic complex: a new family of antiparasitic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 alpha, beta, gamma, lambda. | Carter, GT., et al. 1988. J Antibiot (Tokyo). 41: 519-29. PMID: 3372359
- Mining and engineering exporters for titer improvement of macrolide biopesticides in Streptomyces. | Chu, L., et al. 2022. Microb Biotechnol. 15: 1120-1132. PMID: 34437755
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nemadectin, 1 mg | sc-202239 | 1 mg | $210.00 | |||
Nemadectin, 5 mg | sc-202239A | 5 mg | $790.00 |