NDUFB11 Antibody (E-6): sc-393110

NDUFB11 Antibody (E-6) is a mouse monoclonal IgG3 kappa light chain antibody that detects NDUFB11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-NDUFB11 antibody (E-6) is available as the non-conjugated form. NDUFB11, also known as NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11, plays a crucial role as an accessory subunit of Complex I, which is a key component of the mitochondrial electron transport chain. Complex I is responsible for transferring electrons from NADH to ubiquinone, a process vital for ATP synthesis through oxidative phosphorylation. NDUFB11 is a hydrophobic transmembrane protein that is ubiquitously expressed and localized in the inner mitochondrial membrane. NDUFB11′s structure is essential for the stability and functionality of Complex I, contributing to the assembly and maintenance of this multi-protein complex, which consists of at least 45 different subunits. Additionally, cAMP-dependent phosphorylation of NDUFB11 is significant for regulating Complex I activity, highlighting NDUFB11′s importance in cellular energy metabolism and overall mitochondrial function.

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NDUFB11 Antibody (E-6) References:

1. Cloning and tissue expressional characterization of a full-length cDNA encoding human neuronal protein P17.3.  |  Cui, Y., et al. 1999. Biochem Genet. 37: 175-85. PMID: 10544803
2. Mitochondrial complex I: structure, function and pathology.  |  Janssen, RJ., et al. 2006. J Inherit Metab Dis. 29: 499-515. PMID: 16838076
3. Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development.  |  Gurok, U., et al. 2007. Gene Expr Patterns. 7: 370-4. PMID: 16962385
4. X-linked NDUFA1 gene mutations associated with mitochondrial encephalomyopathy.  |  Fernandez-Moreira, D., et al. 2007. Ann Neurol. 61: 73-83. PMID: 17262856
5. The NDUFB11 gene is not a modifier in Leber hereditary optic neuropathy.  |  Petruzzella, V., et al. 2007. Biochem Biophys Res Commun. 355: 181-7. PMID: 17292333
6. Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors.  |  Lund, KC. and Wallace, KB. 2008. Toxicol Appl Pharmacol. 226: 94-106. PMID: 17904600
7. cAMP-dependent protein kinase regulates the mitochondrial import of the nuclear encoded NDUFS4 subunit of complex I.  |  De Rasmo, D., et al. 2008. Cell Signal. 20: 989-97. PMID: 18291624

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NDUFB11 Antibody (E-6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NDUFB11 Antibody (E-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NDUFB11 Antibody (E-6) Specifications

Alternate Product Name: NDUFB11

Product Clone Name: E-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 1-151

Epitope Target: NDUFB11

Epitope Species: mouse

Product Reactivity/Detection: NDUFB11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NDUFB11 Antibody (E-6): N/A