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NDP (CAS 97860-58-7)

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Alternate Names:
Naphthalene-1,4-dipropionic acid disodium salt
Application:
NDP is a precursor to NDPO2 in the presence of 1O2
CAS Number:
97860-58-7
Molecular Weight:
316.3
Molecular Formula:
C16H14Na2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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NDP, characterized as a water-soluble 1,4-disubstituted naphthalene compound, exhibits a distinctive chemical behavior under specific conditions; it readily undergoes endoperoxide formation, resulting in NDPO2, when exposed to singlet oxygen (1O2). This reaction is of significant interest in the realm of chemical research, especially in studies focused on understanding the dynamics of reactive oxygen species (ROS) and their interactions with various organic compounds. The formation of NDPO2 through the interaction with 1O2 highlights NDP′s role as a pivotal extracellular source of singlet oxygen, offering a unique pathway to generate and study 1O2 in controlled experimental applications. This property is particularly valuable in the investigation of oxidative stress mechanisms, the behavior of singlet oxygen in different environments, and its effects on various substrates, thereby providing a versatile tool in the elucidation of complex biochemical and photochemical processes.


NDP (CAS 97860-58-7) References

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  2. Naphthalene endoperoxides as generators of singlet oxygen in biological media.  |  Pierlot, C., et al. 2000. Methods Enzymol. 319: 3-20. PMID: 10907494
  3. Bactericidal and virucidal activities of singlet oxygen generated by thermolysis of naphthalene endoperoxides.  |  Pellieux, C., et al. 2000. Methods Enzymol. 319: 197-207. PMID: 10907511
  4. Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation.  |  Grether-Beck, S., et al. 2000. EMBO J. 19: 5793-800. PMID: 11060030
  5. On the effect of 1,4-diazabicyclo[2.2.2]octane on the singlet-oxygen dimol emission: chemical generation of 1O2)2 in peroxide reactions.  |  Kazakov, DV., et al. 2007. J Phys Chem A. 111: 4267-73. PMID: 17455924
  6. Whole-Exome Sequencing Reveals Novel NDP Variants in X-Linked Familial Exudative Vitreoretinopathy.  |  Peng, Y., et al. 2022. Eur J Ophthalmol. 32: 3220-3226. PMID: 35037517
  7. Spectrum of Mutations in NDP Resulting in Ocular Disease; a Systematic Review.  |  Wawrzynski, J., et al. 2022. Front Genet. 13: 884722. PMID: 35651932
  8. Ocular manifestations of Chinese patients with copy number variants in the NDP gene.  |  Huang, L., et al. 2022. Mol Vis. 28: 29-38. PMID: 35656167
  9. Clinical Exome Sequencing Identifies NDP Gene Variants in Two Chinese Families with X-Linked Norrie Disease.  |  Zhao, X., et al. 2022. Genet Test Mol Biomarkers. 26: 589-594. PMID: 36577125
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  11. Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy.  |  Morita, A., et al. 1997. J Exp Med. 186: 1763-8. PMID: 9362536
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

NDP, 20 mg

sc-222050
20 mg
$300.00