NCI-H460 Whole Cell Lysate: sc-364235

NCI-H460 whole cell lysate is derived from the NCI-H460 cell line, which originates from a human large cell lung carcinoma. This lysate is extensively utilized in research to study the molecular mechanisms underlying lung cancer biology and the signaling pathways involved in tumor growth, proliferation, and metastasis. NCI-H460 cells are known for their aggressive growth characteristics, making them an ideal model for investigating cancer progression. Researchers employ NCI-H460 whole cell lysate to analyze key signaling pathways such as the PI3K/Akt/mTOR, Ras-MAPK/ERK, and Wnt/β-catenin pathways, which are critical for regulating cell proliferation, survival, and migration. This lysate facilitates the study of protein expression, post-translational modifications, and interactions between signaling molecules that drive these pathways. Additionally, it is used to assess the impact of various chemical modulators on these signaling pathways, providing insights into the regulatory mechanisms of lung cancer cell behavior. Recent studies have leveraged NCI-H460 whole cell lysate for proteomic and genomic analyses to identify novel biomarkers and signaling networks involved in lung cancer. By offering detailed insights into the molecular and cellular mechanisms of lung cancer, NCI-H460 whole cell lysate remains a vital resource for advancing research in oncology and understanding the complexities of cancer signaling.