NBQX disodium salt is a water soluble, selective, and potent GluR (AMPA/kainate receptor) antagonist. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science, 241, 701 (1988) Differential effects of the excitatory amino acid antagonists, 6-cyano- 7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4- yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990)
Soluble in water (5 mg/ml), and DMSO.
Store at -20° C
n20D ~1.82 (Predicted)
PABP: IC50 >66 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Cu llarCu llar, R. et al. (PubMed 26303494) tested the hypothesis that AMPA contributes to glucose regulation in vivo modulating the hyperglycemic reflex with brain glucose retention. They microinjected AMPA and NBQX (AMPA antagonist) into the commissural nucleus tractus solitarii before carotid chemoreceptor stimulation in anesthetized normal Wistar rats, while hyperglycemic reflex and brain glucose retention were analyzed. -SCBT Publication Review
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