NBQX disodium salt CAS: 479347-86-9
MF: C12H6N4O6S•2Na
MW: 380.24
A selective and potent AMPA- and kainate-sensitive glutamate receptor antagonist.

NBQX disodium salt (CAS 479347-86-9)

NBQX disodium salt | CAS 479347-86-9 is rated 5.0 out of 5 by 1.
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Synonym: 6-Nitro-7-sulphamoylbenzo(f)-quinoxaline-2,3-dione . 2Na; FG 9202 disodium salt
Application: A selective and potent AMPA- and kainate-sensitive glutamate receptor antagonist
CAS Number: 479347-86-9
Purity: ≥98%
Molecular Weight: 380.24
Molecular Formula: C12H6N4O6S•2Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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NBQX disodium salt is a water soluble, selective, and potent GluR (AMPA/kainate receptor) antagonist. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4.


References

Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science, 241, 701 (1988) Differential effects of the excitatory amino acid antagonists, 6-cyano- 7-nitroquinoxaline-2,3-dione (CNQX) and 3-((+-)-2-carboxypiperazin-4- yl)-propyl-1-phosphonic acid (CPP), on spinal reflex activity in mice: L. Turski, et al.; Neurosci. Lett. 113, 66 (1990)

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml), and DMSO.
Storage :
Store at -20° C
Refractive Index :
n20D ~1.82 (Predicted)
IC50 :
PABP: IC50 >66 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DK7235000
PubChem CID :
6098006
MDL Number :
MFCD00274065
SMILES :
C1=CC2=C3C(=CC(=C2C(=C1)S(=O)(=O)N)[N+](=O)[O-])N=C(C(=N3)[O-])[O-].[Na+].[Na+]

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Certificate of Analysis

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NBQX disodium salt  Product Citations

See how others have used NBQX disodium salt. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25963821  Vossel, KA. et al. 2015. The Journal of cell biology. 209: 419-33.

PMID: # 32109363  Neuron.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Cu llar Cu llar, R. et al. (PubMed 26303494) tested the hypothesis that AMPA contributes to glucose regulation in vivo modulating the hyperglycemic reflex with brain glucose retention. They microinjected AMPA and NBQX (AMPA antagonist) into the commissural nucleus tractus solitarii before carotid chemoreceptor stimulation in anesthetized normal Wistar rats, while hyperglycemic reflex and brain glucose retention were analyzed. -SCBT Publication Review
Date published: 2015-03-21
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