Molecular structure of Nanaomycin αA, CAS Number: 58286-56-9
Nanaomycin αA (CAS 58286-56-9)
Alternate Names:
Nanaomycin αA is also known as Nanaomycin A methyl ester.
Application:
Nanaomycin αA is a selective Dnmt3b inhibitor with antibiotic, antimycoplasmic, and antifugal properties.
CAS Number:
58286-56-9
Molecular Weight:
316.31
Molecular Formula:
C17H16O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Nanaomycin αA is a selective Dnmt3b inhibitor with antibiotic, antimycoplasmic, and antifugal properties. Nanaomycin αA is also an inducer of antiproliferative effects in tumor cell lines and a Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor. Originating from Streptomyces, Nanaomycin αA is classified as a quinone bacterial metabolite. In addition, Nanaomycin αA also inhibits growth of the plant pathogenic fungus P. oryzae.
Nanaomycin αA (CAS 58286-56-9) References
- Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol. | Tanaka, Y., et al. 1999. J Antibiot (Tokyo). 52: 880-8. PMID: 10604757
- Nanaomycins, new antibiotics produced by a strain of Streptomyces. I. Taxonomy, isolation, characterization and biological properties. | Tanaka, H., et al. 1975. J Antibiot (Tokyo). 28: 860-7. PMID: 1201969
- Nanaomycins, new antibiotics produced by a strain of Streptomyces. III. A new component, nanaomycin C, and biological activities of nanaomycin derivatives. | Tanaka, H., et al. 1975. J Antibiot (Tokyo). 28: 925-30. PMID: 1206004
- Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. | Kuck, D., et al. 2010. Mol Cancer Ther. 9: 3015-23. PMID: 20833755
- 2754A: a new inhibitor of VEGFR-2 isolated from the Streptomyces sp. 2754. | Jiang, ZK., et al. 2010. J Antibiot (Tokyo). 63: 721-3. PMID: 20959849
- A model to predict anti-tuberculosis activity: value proposition for marine microorganisms. | Liu, M., et al. 2016. J Antibiot (Tokyo). 69: 594-9. PMID: 27406906
- Four New Nanaomycins Produced by Streptomyces hebeiensis Derived from Lichen. | Liu, C., et al. 2017. Chem Biodivers. 14: PMID: 28390085
- The mode of action of nanaomycin A in Gram-positive bacteria. | Marumo, H., et al. 1980. J Antibiot (Tokyo). 33: 885-90. PMID: 6159343
Inhibitor of:
Dnmt3b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nanaomycin αA, 1 mg | sc-396527 | 1 mg | $245.00 | |||
Nanaomycin αA, 5 mg | sc-396527A | 5 mg | $1103.00 |