NAMALWA Cell Lysate: sc-2234

NAMALWA cell lysate is derived from the NAMALWA cell line, which originates from a human Burkitt's lymphoma. This lysate is extensively used in research to study the molecular mechanisms of lymphoma, particularly the signaling pathways involved in cell proliferation, apoptosis, and immune response. NAMALWA cells are known for their high expression of Epstein-Barr virus (EBV) nuclear antigen, making them an ideal model for investigating virus-associated lymphomas. Researchers utilize NAMALWA cell lysate to analyze key signaling pathways such as the NF-κB, PI3K/Akt, and JAK/STAT pathways, which are crucial for regulating cell growth and survival. This lysate facilitates the study of protein expression, post-translational modifications, and interactions between signaling molecules that drive these pathways. Additionally, it is used to examine the effects of various chemical modulators on these signaling pathways, providing insights into the regulatory mechanisms of lymphoma cell behavior and response to viral oncogenesis. Recent studies have leveraged NAMALWA cell lysate for proteomic and genomic analyses to identify novel biomarkers and signaling networks involved in lymphoma progression. By offering detailed insights into the molecular and cellular mechanisms of lymphoma, NAMALWA cell lysate remains a vital resource for advancing research in oncology and understanding complex lymphoma signaling pathways.

NAMALWA Cell Lysate References:

1. Molecular analysis of the prostate-specific antigen upstream gene enhancer.  |  Farmer, G., et al. 2001. Prostate. 46: 76-85. PMID: 11170135
2. Purification of immunoglobulin production stimulation factor II alpha derived from Namalwa cells.  |  Sugahara, T., et al. 1991. Cytotechnology. 5: 255-63. PMID: 1367378
3. Purification and characterization of immunoglobulin production stimulating factor-II beta derived from Namalwa cells.  |  Sugahara, T., et al. 1992. Cytotechnology. 10: 137-46. PMID: 1369209
4. Selective production of interferon-alpha subtypes by cultured peripheral blood mononuclear cells and lymphoblastoid cell lines.  |  Greenway, AL., et al. 1992. Immunology. 75: 182-8. PMID: 1537595
5. HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma.  |  Zappasodi, R., et al. 2015. Blood. 125: 1768-71. PMID: 25573990
6. Partial purification and characterization of immunoglobulin production stimulating factor derived from Namalwa cells.  |  Yamada, K., et al. 1989. In Vitro Cell Dev Biol. 25: 243-7. PMID: 2925563
7. The mode of actions of glyceraldehyde-3-phosphate dehydrogenase identified as an immunoglobulin production stimulating factor.  |  Sugahara, T., et al. 1995. FEBS Lett. 368: 92-6. PMID: 7615095
8. Enhancement of immunoglobulin productivity of human-human hybridoma HB4C5 cells by basic proteins and poly-basic amino acids.  |  Sugahara, T., et al. 1994. Biosci Biotechnol Biochem. 58: 2212-4. PMID: 7765714
9. Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains.  |  Finan, PM., et al. 1996. J Biol Chem. 271: 26291-5. PMID: 8824280
10. Monoclonal antibodies specific to the acute lymphoblastic leukemia t(1;19)-associated E2A/pbx1 chimeric protein: characterization and diagnostic utility.  |  Sang, BC., et al. 1997. Blood. 89: 2909-14. PMID: 9108411
11. Synthesis, uptake, and intracellular metabolism of a hydrophobic tetrapeptide-peptide nucleic acid (PNA)-biotin molecule.  |  Scarfi, S., et al. 1997. Biochem Biophys Res Commun. 236: 323-6. PMID: 9240433
12. Alcohol dehydrogenase-I from horse liver stimulates immunoglobulin production by human hybridoma and human peripheral blood lymphocytes.  |  Sugahara, T., et al. 1997. Mol Cell Biochem. 173: 113-9. PMID: 9278261
13. A novel function of enolase from rabbit muscle; an immunoglobulin production stimulating factor.  |  Sugahara, T., et al. 1998. Biochim Biophys Acta. 1380: 163-76. PMID: 9565679