Molecular structure of N4-Acetylcytidine, CAS Number: 3768-18-1
N4-Acetylcytidine (CAS 3768-18-1)
See product citations (2)
Alternate Names:
N4-Acetyl-D-cytidine
CAS Number:
3768-18-1
Purity:
≥95%
Molecular Weight:
285.25
Molecular Formula:
C11H15N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
N4-Acetylcytidine (N4-Ac) is a biological compound present in various organisms, including humans. It serves as a derivative of cytidine, a naturally occurring nucleoside, and plays a vital role as a foundational element in protein synthesis. Also known as 4-acetylcytidine, N4-Acetylcytidine finds extensive utility in scientific research and development. Its applications encompass diverse areas such as investigating protein and molecular structures, exploring gene expression and regulation. Additionally, N4-Acetylcytidine functions as a protein synthesis inhibitor by binding to the ribosomal subunit, impeding the association of aminoacyl-tRNA. This interference hampers the formation of peptide bonds, effectively inhibiting protein synthesis.
N4-Acetylcytidine (CAS 3768-18-1) References
- Acetylation of Cytidine in mRNA Promotes Translation Efficiency. | Arango, D., et al. 2018. Cell. 175: 1872-1886.e24. PMID: 30449621
- Nucleotide resolution sequencing of N4-acetylcytidine in RNA. | Thomas, JM., et al. 2019. Methods Enzymol. 621: 31-51. PMID: 31128786
- PACES: prediction of N4-acetylcytidine (ac4C) modification sites in mRNA. | Zhao, W., et al. 2019. Sci Rep. 9: 11112. PMID: 31366994
- Epitranscriptomic N4-Acetylcytidine Profiling in CD4+ T Cells of Systemic Lupus Erythematosus. | Guo, G., et al. 2020. Front Cell Dev Biol. 8: 842. PMID: 32984334
- XG-ac4C: identification of N4-acetylcytidine (ac4C) in mRNA using eXtreme gradient boosting with electron-ion interaction pseudopotentials. | Alam, W., et al. 2020. Sci Rep. 10: 20942. PMID: 33262392
- NAT10-Mediated N4-Acetylcytidine of RNA Contributes to Post-transcriptional Regulation of Mouse Oocyte Maturation in vitro. | Xiang, Y., et al. 2021. Front Cell Dev Biol. 9: 704341. PMID: 34395433
- Pan-cancer analysis of N4-acetylcytidine adaptor THUMPD1 as a predictor for prognosis and immunotherapy. | Li, K., et al. 2021. Biosci Rep. 41: PMID: 34762107
- CNNLSTMac4CPred: A Hybrid Model for N4-Acetylcytidine Prediction. | Zhang, G., et al. 2022. Interdiscip Sci. 14: 439-451. PMID: 35106702
- Uncovering N4-Acetylcytidine-Related mRNA Modification Pattern and Landscape of Stemness and Immunity in Hepatocellular Carcinoma. | Liu, S., et al. 2022. Front Cell Dev Biol. 10: 861000. PMID: 35493106
- Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. | Arango, D., et al. 2022. Mol Cell. 82: 2797-2814.e11. PMID: 35679869
- NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells. | Chen, L., et al. 2022. Nucleic Acids Res. 50: 10896-10913. PMID: 35801907
- N4-acetylcytidine regulates the replication and pathogenicity of enterovirus 71. | Hao, H., et al. 2022. Nucleic Acids Res. 50: 9339-9354. PMID: 35971620
- Comprehensive Analysis of Long Non-Coding RNAs N4-Acetylcytidine in Alzheimer's Disease Mice Model Using High-Throughput Sequencing. | Ma, Y., et al. 2022. J Alzheimers Dis. 90: 1659-1675. PMID: 36314201
- Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression. | Deng, M., et al. 2023. J Exp Clin Cancer Res. 42: 9. PMID: 36609449
- N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing. | Yu, XM., et al. 2023. Oncogene. 42: 1101-1116. PMID: 36792757
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N4-Acetylcytidine, 5 g | sc-222023B | 5 g | $89.00 | |||
N4-Acetylcytidine, 10 g | sc-222023A | 10 g | $143.00 | |||
N4-Acetylcytidine, 25 g | sc-222023 | 25 g | $213.00 | |||
N4-Acetylcytidine, 50 g | sc-222023C | 50 g | $335.00 | |||
N4-Acetylcytidine, 100 g | sc-222023D | 100 g | $576.00 |