Date published: 2025-12-19

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N4-Acetyl-2′-deoxycytidine (CAS 32909-05-0)

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Alternate Names:
NAc-2′-dC
CAS Number:
32909-05-0
Molecular Weight:
269.3
Molecular Formula:
C11H15N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N4-Acetyl-2′-deoxycytidine (N4A2dC) holds significant importance in the realm of biochemistry and molecular biology. N4-Acetyl-2′-deoxycytidine plays a pivotal role in DNA and RNA structures, ensuring proper cellular functioning. It serves as a DNA repair marker and contributes to the study of gene expression and regulation. N4-Acetyl-2′-deoxycytidine is believed to act as a methylation donor during DNA repair, contributing to the intricate processes involved. Additionally, it is thought to partake in the regulation of gene expression by serving as a methylation donor for histone proteins. Furthermore, N4-Acetyl-2′-deoxycytidine is deemed involved in the control of gene transcription through its role as a methylation donor for the transcription factor TFIIIA.


N4-Acetyl-2′-deoxycytidine (CAS 32909-05-0) References

  1. Sensitized photochemistry of di(4-tetrazolouracil) dinucleoside monophosphate as a route to dicytosine cyclobutane photoproduct precursors.  |  Peyrane, F. and Clivio, P. 2013. Photochem Photobiol Sci. 12: 1366-74. PMID: 23572020
  2. Solid-Phase Synthesis, Hybridizing Ability, Uptake, and Nuclease Resistant Profiles of Position-Selective Cationic and Hydrophobic Phosphotriester Oligonucleotides.  |  Monfregola, L. and Caruthers, MH. 2015. J Org Chem. 80: 9147-58. PMID: 26317155
  3. YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine derivatives.  |  Stanislauskienė, R., et al. 2020. Sci Rep. 10: 788. PMID: 31964920
  4. Functionalized Protein Nanotubes Based on the Bacteriophage vB_KleM-RaK2 Tail Sheath Protein.  |  Labutytė, G., et al. 2021. Nanomaterials (Basel). 11: PMID: 34835795
  5. A DNA adductome analysis revealed a reduction in the global level of C5-hydroxymethyl-2'-deoxycytidine in the non-tumoral upper urinary tract mucosa of urothelial carcinoma patients.  |  Matsushita, Y., et al. 2021. Genes Environ. 43: 52. PMID: 34852853
  6. N4-acetyldeoxycytosine DNA modification marks euchromatin regions in Arabidopsis thaliana.  |  Wang, S., et al. 2022. Genome Biol. 23: 5. PMID: 34980211
  7. Comparative Analysis of Mesophilic YqfB-Type Amidohydrolases.  |  Statkevičiūtė, R., et al. 2022. Biomolecules. 12: PMID: 36291701
  8. Cytidine deaminases catalyze the conversion of N(S,O)4-substituted pyrimidine nucleosides.  |  Urbelienė, N., et al. 2023. Sci Adv. 9: eade4361. PMID: 36735785
  9. The use of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in the selective N4-acylation of cytidine and its derivatives.  |  Mercer, JF. and Symons, RH. 1971. Biochim Biophys Acta. 238: 27-30. PMID: 5576621

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N4-Acetyl-2′-deoxycytidine, 1 g

sc-295825
1 g
$20.00

N4-Acetyl-2′-deoxycytidine, 5 g

sc-295825A
5 g
$46.00