N-Demethyl Erythromycin A (CAS 992-62-1)
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N-Demethyl Erythromycin A is a derivative of the macrolide antibiotic erythromycin, characterized by the removal of a methyl group from the nitrogen atom in the erythromycin molecule. This structural modification impacts its interaction with the bacterial ribosomal RNA, specifically targeting the 50S ribosomal subunit. By binding to this site, N-Demethyl Erythromycin A interferes with the translocation process of the ribosome along the messenger RNA (mRNA), ultimately inhibiting protein synthesis within bacterial cells. This mechanism highlights its role as a vital tool in molecular biology and antibiotic mechanism research, providing insights into the nuances of ribosomal function and antibiotic resistance mechanisms. Its utility extends into studies focused on elucidating the structural and functional dynamics of bacterial ribosomes, thereby contributing to a deeper understanding of macrolide antibiotic interactions and the development of novel antimicrobial agents.
N-Demethyl Erythromycin A (CAS 992-62-1) References
- Determination of erythromycin and related substances in enteric-coated tablet formulations by reversed-phase liquid chromatography. | Wardrop, J., et al. 2000. J Pharm Sci. 89: 1097-105. PMID: 10944374
- Analysis of unknown compounds in azithromycin bulk samples with liquid chromatography coupled to ion trap mass spectrometry. | Debremaeker, D., et al. 2003. Rapid Commun Mass Spectrom. 17: 342-50. PMID: 12569445
- Analysis of erythromycin estolate by liquid chromatography. | Cachet, T., et al. 1992. J Pharm Biomed Anal. 10: 851-60. PMID: 1298393
- Identification of impurities in erythromycin by liquid chromatography-mass spectrometric detection. | Kumar Chitneni, S., et al. 2004. J Chromatogr A. 1056: 111-20. PMID: 15595540
- Quantitative analysis of erythromycin by reversed-phase liquid chromatography using column-switching. | Cachet, T., et al. 1991. J Pharm Biomed Anal. 9: 547-55. PMID: 1817675
- Tissue distribution and excretion of radioactively labelled compounds in the Wistar rat after administration of [N-methyl-14C]-erythromycin A. | Kibwage, IO., et al. 1989. Eur J Drug Metab Pharmacokinet. 14: 7-14. PMID: 2759136
- Thin-layer chromatographic study of the metabolites of erythromycins in the Wistar rat. | Kibwage, IO., et al. 1988. J Chromatogr. 434: 177-86. PMID: 3243811
- Simultaneous determination of erythromycin and its transformation products in treated erythromycin fermentation residue and amended soil. | Feng, H., et al. 2023. Chemosphere. 313: 137414. PMID: 36455662
- Optimization of the separation of erythromycin and related substances by high-performance liquid chromatography. | Cachet, T., et al. 1987. J Chromatogr. 409: 91-100. PMID: 3693497
- Separation of erythromycin and related substances by high-performance liquid chromatography on poly(styrene-divinylbenzene) packing materials. | Kibwage, IO., et al. 1985. J Chromatogr. 330: 275-86. PMID: 4066823
- Semi-automated preparation of a 11C-labelled antibiotic--[N-methyl-11C]erythromycin A lactobionate. | Pike, VW., et al. 1984. Int J Appl Radiat Isot. 35: 103-9. PMID: 6231252
- Determination of erythromycin and related substances by capillary electrophoresis. | Lalloo, AK. and Kanfer, I. 1997. J Chromatogr B Biomed Sci Appl. 704: 343-50. PMID: 9518168
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Demethyl Erythromycin A, 5 mg | sc-212175 | 5 mg | $273.00 |