N-Boc-γ-aminobutyric acid (CAS 57294-38-9)
QUICK LINKS
N-Boc-γ-aminobutyric acid functions as a protecting group for the γ-aminobutyric acid (GABA) moiety. It is utilized in peptide synthesis to protect the amine group of GABA, allowing for selective manipulation of other functional groups. The N-Boc group is typically removed under mild acidic conditions, enabling the synthesis of GABA-containing peptides. N-Boc-γ-Aminobutyric Acid′s mechanism of action involves the reversible protection of the amine group, preventing unwanted reactions during peptide synthesis. By serving as a protecting group, N-Boc-γ-aminobutyric acid facilitates the controlled modification of GABA-containing peptides, contributing to the synthesis of complex peptide structures. Its role in peptide synthesis involves the precise manipulation of functional groups, allowing for the creation of diverse peptide sequences without affecting the GABA moiety.
N-Boc-γ-aminobutyric acid (CAS 57294-38-9) References
- Non-peptidic, non-prenylic bisubstrate farnesyltransferase inhibitors. Part 3: structural requirements of the central moiety for farnesyltransferase inhibitory activity. | Schlitzer, M., et al. 2000. Bioorg Med Chem. 8: 2399-406. PMID: 11058034
- Non-thiol farnesyltransferase inhibitors: structure-activity relationships of benzophenone-based bisubstrate analogue farnesyltransferase inhibitors. | Schlitzer, M., et al. 2002. Bioorg Med Chem. 10: 615-20. PMID: 11814849
- Fluorinated photoremovable protecting groups: the influence of fluoro substituents on the photo-Favorskii rearrangement. | Stensrud, KF., et al. 2008. Photochem Photobiol Sci. 7: 614-24. PMID: 18465018
- Synthesis and antibacterial activity evaluation of metronidazole-triazole conjugates. | Beena, ., et al. 2009. Bioorg Med Chem Lett. 19: 1396-8. PMID: 19195884
- p-Hydroxyphenacyl photoremovable protecting groups - Robust photochemistry despite substituent diversity. | Givens, RS., et al. 2011. Can J Chem. 89: 364-384. PMID: 24436496
- Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease. | Shen, S., et al. 2016. ACS Chem Neurosci. 7: 240-58. PMID: 26599234
- Cellular Activity of New Small Molecule Protein Arginine Deiminase 3 (PAD3) Inhibitors. | Jamali, H., et al. 2016. ACS Med Chem Lett. 7: 847-51. PMID: 27660689
- Development of selective mono or dual PROTAC degrader probe of CDK isoforms. | Zhou, F., et al. 2020. Eur J Med Chem. 187: 111952. PMID: 31846828
- Discovery of a d-pro-lys peptidomimetic inhibitor of MMP9: Addressing the gelatinase selectivity beyond S1' subsite. | Lenci, E., et al. 2020. Bioorg Med Chem Lett. 30: 127467. PMID: 32768649
- Novel Benzoxazoles Containing 4-Amino-Butanamide Moiety Inhibited LPS-Induced Inflammation by Modulating IL-6 or IL-1β mRNA Expression. | Yoo, J., et al. 2022. Int J Mol Sci. 23: PMID: 35628136
- Folic acid functionalization for targeting self-assembled paclitaxel-based nanoparticles. | Colombo, E., et al. 2022. RSC Adv. 12: 35484-35493. PMID: 36544466
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
N-Boc-γ-aminobutyric acid, 1 g | sc-279719 | 1 g | $49.00 |