Date published: 2025-12-27

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N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt (CAS 357965-99-2)

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Alternate Names:
N-(4S)-(4-amino-5-[aminoethyl]aminopentyl)-N′-nitroguanidine tris(trifluoroacetate) salt
Application:
N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt is a cell-permeable, potent and highly selective inhibitor of NOS1 (nNOS)
CAS Number:
357965-99-2
Purity:
≥95%
Molecular Weight:
589.37
Molecular Formula:
C14H24N7O8F9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt is often employed in biochemical research due to its role as a nitric oxide synthase inhibitor, which allows for the exploration of nitric oxide production and regulation. This compound is particularly useful in studying the enzymatic mechanisms that control vascular tone and neurotransmission, as nitric oxide plays a pivotal role in these processes. By inhibiting nitric oxide synthase, researchers are able to observe the downstream effects of reduced nitric oxide levels in various biological systems. N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt is also used to understand the contribution of nitric oxide to immune system function and cellular signaling pathways. Moreover, its use extends to research on the impact of nitric oxide on gene expression and protein modification, which is critical in elucidating the complex network of cellular responses.


N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt (CAS 357965-99-2) References

  1. Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery: involvement of nitric oxide and an additional unidentified neurotransmitter.  |  Overend, J., et al. 2005. Br J Pharmacol. 145: 1001-8. PMID: 15912133
  2. The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice.  |  Hervera, A., et al. 2010. J Pharmacol Exp Ther. 334: 887-96. PMID: 20498253
  3. Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis.  |  Hooper, CL., et al. 2013. Am J Physiol Heart Circ Physiol. 304: H1302-13. PMID: 23504181
  4. DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol.  |  Gorska, M., et al. 2015. Oncotarget. 6: 15449-63. PMID: 25972363

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt, 5 mg

sc-215427
5 mg
$148.00

N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N′-nitroguanidine tris(trifluoroacetate) salt, 25 mg

sc-215427A
25 mg
$719.00