Msx-1 Antibody (5D11): sc-517256

Msx-1 Antibody (5D11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Msx-1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Msx-1 antibody (5D11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Msx-1 plays a crucial role in embryonic development as a transcription factor that regulates morphogenesis, particularly at sites of epithelial-mesenchymal interaction, such as during tooth development. Msx-1 is essential for proper formation of the craniofacial skeleton and is involved in down-regulation of a master gene responsible for skeletal cell differentiation. Msx-1 is expressed in various tissues, including epidermis, hair follicles, and fibroblasts of developing fetal skin, with expression in adult skin being limited to epithelially derived structures. Dynamic expression patterns of Msx-1 and interaction with Msx-2 during critical developmental stages, such as neural tube and neural crest formation, underscore their importance in organogenesis and highlight the necessity of studying these proteins for understanding developmental biology and potential implications in regenerative medicine.

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Msx-1 Antibody (5D11) References:

1. Biomineralization, life-time of odontogenic cells and differential expression of the two homeobox genes MSX-1 and DLX-2 in transgenic mice.  |  Lézot, F., et al. 2000. J Bone Miner Res. 15: 430-41. PMID: 10750557
2. Endogenous Msx1 antisense transcript: in vivo and in vitro evidences, structure, and potential involvement in skeleton development in mammals.  |  Blin-Wakkach, C., et al. 2001. Proc Natl Acad Sci U S A. 98: 7336-41. PMID: 11390985
3. Msx-1 and Msx-2 in mammary gland development.  |  Satoh, K., et al. 2004. J Mammary Gland Biol Neoplasia. 9: 195-205. PMID: 15300013
4. Msx-1 is suppressed in bisphosphonate-exposed jaw bone analysis of bone turnover-related cell signalling after bisphosphonate treatment.  |  Wehrhan, F., et al. 2011. Oral Dis. 17: 433-42. PMID: 21366807
5. Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus.  |  Shen, Z., et al. 2024. J Virol. 98: e0134523. PMID: 38226815
6. Multiple amino acids determine the DNA binding specificity of the Msx-1 homeodomain.  |  Isaac, VE., et al. 1995. Biochemistry. 34: 7127-34. PMID: 7766623
7. Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development.  |  Phippard, DJ., et al. 1996. Development. 122: 2729-37. PMID: 8787747
8. Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy.  |  Catron, KM., et al. 1996. Mech Dev. 55: 185-99. PMID: 8861098
9. The genetic control of early tooth development.  |  Maas, R. and Bei, M. 1997. Crit Rev Oral Biol Med. 8: 4-39. PMID: 9063623
10. Disruption of Msx-1 and Msx-2 reveals roles for these genes in craniofacial, eye, and axial development.  |  Foerst-Potts, L. and Sadler, TW. 1997. Dev Dyn. 209: 70-84. PMID: 9142497
11. The human homeobox genes MSX-1, MSX-2, and MOX-1 are differentially expressed in the dermis and epidermis in fetal and adult skin.  |  Stelnicki, EJ., et al. 1997. Differentiation. 62: 33-41. PMID: 9373945
12. MSX-1 gene expression and regulation in embryonic palatal tissue.  |  Nugent, P. and Greene, RM. 1998. In Vitro Cell Dev Biol Anim. 34: 831-5. PMID: 9870533

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Msx-1 Antibody (5D11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Msx-1 Antibody (5D11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Msx-1 Antibody (5D11) Specifications

Alternate Product Name: Msx-1

Product Clone Name: 5D11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 16-243

Epitope Target: Msx-1

Epitope Species: human

Product Reactivity/Detection: Msx-1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Msx-1 Antibody (5D11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin