Date published: 2025-9-24

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MRS 2768 tetrasodium salt (CAS 1047980-83-5)

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Alternate Names:
Uridine-5′-tetraphosphate δ-phenyl ester tetrasodium salt
CAS Number:
1047980-83-5
Purity:
≥98%
Molecular Weight:
728.14
Molecular Formula:
C15H16N2O18P4Na4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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MRS 2768 tetrasodium salt is a selective purinergic receptor agonist, specifically targeting the P2Y2 receptor subtype. In research, it is employed to study the physiological and pathological roles of P2Y2 receptors in cellular communication. The compound′s affinity for these receptors makes it a useful tool for dissecting signal transduction pathways that rely on extracellular nucleotides, which are implicated in a range of biological processes including ion transport regulation, inflammation, and tissue repair. By activating P2Y2 receptors, MRS 2768 tetrasodium salt helps in understanding the receptor′s involvement in the modulation of intracellular calcium levels and its potential impact on the function of epithelial cells and various other cell types. In addition, it′s utilized in assay development for screening compounds with potential effects on purinergic signaling. The tetrasodium salt form of MRS 2768 ensures high solubility in aqueous solutions, facilitating its use in various experimental setups.


MRS 2768 tetrasodium salt (CAS 1047980-83-5) References

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  2. Adenine nucleotide control of coronary blood flow during exercise.  |  Gorman, MW., et al. 2010. Am J Physiol Heart Circ Physiol. 299: H1981-9. PMID: 20852039
  3. Purinergic modulation of the excitatory synaptic input onto rat striatal neurons.  |  Tautenhahn, M., et al. 2012. Neuropharmacology. 62: 1756-66. PMID: 22182780
  4. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.  |  Shabir, S., et al. 2013. Am J Physiol Renal Physiol. 305: F396-406. PMID: 23720349
  5. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli.  |  Ilatovskaya, DV., et al. 2013. Am J Physiol Cell Physiol. 305: C1050-9. PMID: 24048730
  6. ADP-induced bladder contractility is mediated by P2Y12 receptor and temporally regulated by ectonucleotidases and adenosine signaling.  |  Yu, W., et al. 2014. FASEB J. 28: 5288-98. PMID: 25208846
  7. Extracellular acidosis impairs P2Y receptor-mediated Ca(2+) signalling and migration of microglia.  |  Langfelder, A., et al. 2015. Cell Calcium. 57: 247-56. PMID: 25623949
  8. Involvement of nucleotides in glial growth following scratch injury in avian retinal cell monolayer cultures.  |  Silva, TM., et al. 2015. Purinergic Signal. 11: 183-201. PMID: 25663277
  9. Calcium signaling and the novel anti-proliferative effect of the UTP-sensitive P2Y11 receptor in rat cardiac myofibroblasts.  |  Certal, M., et al. 2015. Cell Calcium. 58: 518-33. PMID: 26324417
  10. Role of P2 Receptors as Modulators of Rat Eosinophil Recruitment in Allergic Inflammation.  |  Alberto, AV., et al. 2016. PLoS One. 11: e0145392. PMID: 26784445
  11. P2Y2 receptor modulates shear stress-induced cell alignment and actin stress fibers in human umbilical vein endothelial cells.  |  Sathanoori, R., et al. 2017. Cell Mol Life Sci. 74: 731-746. PMID: 27652381
  12. Coupling of P2Y receptors to Ca2+ mobilization in mesenchymal stromal cells from the human adipose tissue.  |  Kotova, PD., et al. 2018. Cell Calcium. 71: 1-14. PMID: 29604959
  13. Clopidogrel treatment inhibits P2Y2-Mediated constriction in the rabbit middle cerebral artery.  |  Kuszynski, DS., et al. 2021. Eur J Pharmacol. 911: 174545. PMID: 34606835
  14. Absence of P2Y2 Receptor Does Not Prevent Bone Destruction in a Murine Model of Muscle Paralysis-Induced Bone Loss.  |  Agrawal, A., et al. 2022. Front Endocrinol (Lausanne). 13: 850525. PMID: 35721713

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MRS 2768 tetrasodium salt, 1 mg

sc-311440
1 mg
$299.00
US: Only available in the US