MRP6 Antibody (M6II-7): sc-57528

MRP6 Antibody (M6II-7) is a rat monoclonal IgG2a antibody that detects MRP6 of human origin by western blotting (WB) and immunofluorescence (IF). Anti-MRP6 antibody (M6II-7) is available in a non-conjugated form, allowing for versatile applications in research. MRP6, a member of the ATP-binding cassette (ABC) transporter family, plays a crucial role in the transport of various substrates across cellular membranes, which is vital for maintaining cellular homeostasis and drug resistance in cancer cells. MRP6 is predominantly expressed in the liver and kidney, where MRP6 facilitates the excretion of organic anions and drugs, thereby influencing pharmacokinetics and the efficacy of therapeutic agents. Proper functioning of MRP6 is essential, as dysregulation can lead to altered drug metabolism and increased toxicity, particularly in the context of multidrug resistance observed in cancer therapies. Understanding the expression and function of MRP6 can provide insights into its role in drug disposition and potential therapeutic interventions.

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MRP6 Antibody (M6II-7) References:

1. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane.  |  König, J., et al. 1999. Hepatology. 29: 1156-63. PMID: 10094960
2. MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte.  |  Ortiz, DF., et al. 1999. Am J Physiol. 276: G1493-500. PMID: 10362653
3. Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene.  |  Stöckel, B., et al. 2000. Eur J Biochem. 267: 1347-58. PMID: 10691972
4. Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein.  |  Versantvoort, CH., et al. 1995. Br J Cancer. 72: 82-9. PMID: 7599070
5. Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver.  |  Keppler, D. and Konig, J. 1997. FASEB J. 11: 509-16. PMID: 9212074
6. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.  |  Kool, M., et al. 1997. Cancer Res. 57: 3537-47. PMID: 9270026
7. Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain.  |  Bakos, E., et al. 1998. J Biol Chem. 273: 32167-75. PMID: 9822694