This polyclonal antibody has been discontinued. See our recommended MRE11 (18) monoclonal antibody (sample data shown).
MRE11 Antibody (C-16): sc-5859
- MRE11 Antibody (C-16) is a goat polyclonal IgG; 200 µg/ml
- epitope mapping near the C-terminus of MRE11 of human origin
- Discontinued polyclonal antibody
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Description
Rad52 family members (Rad50, Rad51B/C/D, Rad52, Rad54 and MRE11) mediate DNA double-strand break repair (DSBR) for DNA damage that could otherwise cause cell death, mutation or neoplastic transformation. Rad51 (RECA, BRCC5) interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of Rad51. Rad52 forms a heptameric ring that binds single-stranded DNA ends and catalyzes DNA-DNA interaction necessary for the annealing of complementary strands. Rad52 can interact with Rad51. MRE11 (meiotic recombination 11, ATLD, HNGS1) is a nuclear 3′ -5′ exonuclease/endonuclease that associates with RAD50 and influences homologous recombination, telomere length maintenance, and DNA double-strand break repair. MRE11 is most abundant in proliferating tissues.
Ordering Information
MRE11 (18): sc-135992 [ Recommended monoclonal replacement for MRE11 (C-16) ]
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MRE11 Antibody (18) | sc-135992 | 200 µg/ml | $322.00 | |||
MRE11 Antibody (18): m-IgG Fc BP-HRP Bundle | sc-528795 | 200 µg Ab; 10 µg BP | $361.00 | |||
MRE11 Antibody (18): m-IgGκ BP-HRP Bundle | sc-521316 | 200 µg Ab, 40 µg BP | $361.00 | |||
MRE11 Antibody (18): m-IgG1 BP-HRP Bundle | sc-543135 | 200 µg Ab; 20 µg BP | $361.00 |