Mos^xe Antibody (B-4): sc-392290

Mosxe Antibody (B-4) is a mouse monoclonal IgM kappa light chain antibody that detects Mosxe protein of Xenopus laevis origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Mosxe antibody (B-4) is available as the non-conjugated form. Mosxe (B-4) antibody recognizes a cellular homolog of the v-Mos oncogene derived from the Moloney strain murine sarcoma virus, which plays a crucial role in regulating meiosis in vertebrate oocytes. Mosxe is encoded by a single exon within the c-Mos proto-oncogene locus, identified in various species, including humans, mice, and chickens. Mosxe (B-4) monoclonal antibody targets a protein essential during oocyte maturation, where Mosxe stabilizes or activates the maturation promoting factor (MPF) complex, a key regulator of the cell cycle. While Mosxe expression remains low in somatic cells, levels increase significantly in germ cells, highlighting a specialized role in reproductive biology. When expressed during the G1 phase of the cell cycle, Mosxe can induce oncogenic transformation of somatic cells, suggesting potential implications in cancer biology. Mosxe activates the mitogen-activated protein kinase (MAPK) pathway through direct phosphorylation of MAPKK MEK-1, emphasizing its importance in cellular signaling and development.

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Mos^xe Antibody (B-4) References:

1. Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA.  |  Mendez, R., et al. 2000. Nature. 404: 302-7. PMID: 10749216
2. Chicken homolog of the mos proto-oncogene.  |  Schmidt, M., et al. 1988. Mol Cell Biol. 8: 923-9. PMID: 2832744
3. Expression of c-mos proto-oncogene transcripts in mouse tissues.  |  Propst, F. and Vande Woude, GF. Nature. 315: 516-8. PMID: 4000280
4. Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.  |  Watson, R., et al. 1982. Proc Natl Acad Sci U S A. 79: 4078-82. PMID: 6287464
5. The role of gene dosage and genetic transpositions in carcinogenesis.  |  Klein, G. 1981. Nature. 294: 313-8. PMID: 7312030
6. Ser-3 is important for regulating Mos interaction with and stimulation of mitogen-activated protein kinase kinase.  |  Chen, M. and Cooper, JA. 1995. Mol Cell Biol. 15: 4727-34. PMID: 7651390
7. MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.  |  Okazaki, K. and Sagata, N. 1995. Oncogene. 10: 1149-57. PMID: 7700641
8. Characterization of MEK1 phosphorylation by the v-Mos protein.  |  Pham, CD., et al. 1995. Oncogene. 10: 1683-8. PMID: 7731726
9. Identification of an autoinhibitory region in the activation loop of the Mos protein kinase.  |  Robertson, SC. and Donoghue, DJ. 1996. Mol Cell Biol. 16: 3472-9. PMID: 8668163

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mos^xe Antibody (B-4) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mos^xe Antibody (B-4) Specifications

Alternate Product Name: Mosxe

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 305-334

Epitope Target: Mos^xe

Epitope Species: Xenopus laevis

Product Reactivity/Detection: Mos p39

Species Reactivity/Detection: x

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Mos^xe Antibody (B-4): N/A