MOSC2 Antibody (H-7): sc-514202
- MOSC2 Antibody (H-7) is a mouse monoclonal IgG1 κ MOSC2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 190-215 within an internal region of MOSC2 of mouse origin
- MOSC2 Antibody (H-7) is recommended for detection of MOSC2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MOSC2 Antibody (H-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MOSC2 Antibody (H-7) for WB applications. These reagents are now offered in bundles with MOSC2 Antibody (H-7) (see ordering information below).
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MOSC2 Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects MOSC2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MOSC2 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MOSC2, also known as MOCO sulphurase C-terminal domain containing 2, is a 335 amino acid peripheral membrane protein primarily localized to mitochondria, where MOSC2 plays a crucial role in cellular metabolism. MOSC2 contains a MOSC domain and utilizes molybdenum as a cofactor, functioning as a key component of the benzamidoxime prodrug-converting complex, which also includes cytochrome β5 and NADH-cytochrome β5 reductase (CYB5R3). The interaction between MOSC2 and CYB5R3 is particularly important, as CYB5R3 is involved in essential processes such as fatty acid desaturation and elongation, cholesterol biosynthesis, and drug metabolism, as well as methemoglobin reduction in erythrocytes. The benzamidoxime prodrug-converting complex is vital for reducing N-hydroxylated structures, including benzamidoxime prodrugs, facilitating their conversion into active forms. MOSC2 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 1q41, highlighting MOSC2′s significance in both normal physiology and potential pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MOSC2 Antibody (H-7) References:
- Reduction of N-hydroxylated compounds: amidoximes (N-hydroxyamidines) as pro-drugs of amidines. | Clement, B. 2002. Drug Metab Rev. 34: 565-79. PMID: 12214667
- The roles of cytochrome b5 in cytochrome P450 reactions. | Porter, TD. 2002. J Biochem Mol Toxicol. 16: 311-6. PMID: 12481306
- The many roles of cytochrome b5. | Schenkman, JB. and Jansson, I. 2003. Pharmacol Ther. 97: 139-52. PMID: 12559387
- Recessive congenital methaemoglobinaemia: functional characterization of the novel D239G mutation in the NADH-binding lobe of cytochrome b5 reductase. | Percy, MJ., et al. 2005. Br J Haematol. 129: 847-53. PMID: 15953014
- Identification of the missing component in the mitochondrial benzamidoxime prodrug-converting system as a novel molybdenum enzyme. | Havemeyer, A., et al. 2006. J Biol Chem. 281: 34796-802. PMID: 16973608
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MOSC2 Antibody (H-7) | sc-514202 | 200 µg/ml | $316.00 | |||
MOSC2 Antibody (H-7): m-IgG Fc BP-HRP Bundle | sc-527865 | 200 µg Ab; 10 µg BP | $354.00 | |||
MOSC2 Antibody (H-7): m-IgG1 BP-HRP Bundle | sc-533238 | 200 µg Ab; 20 µg BP | $354.00 | |||
MOSC2 Antibody (H-7) AC | sc-514202 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MOSC2 Antibody (H-7) HRP | sc-514202 HRP | 200 µg/ml | $316.00 | |||
MOSC2 Antibody (H-7) FITC | sc-514202 FITC | 200 µg/ml | $330.00 | |||
MOSC2 Antibody (H-7) PE | sc-514202 PE | 200 µg/ml | $343.00 | |||
MOSC2 Antibody (H-7) Alexa Fluor® 488 | sc-514202 AF488 | 200 µg/ml | $357.00 | |||
MOSC2 Antibody (H-7) Alexa Fluor® 546 | sc-514202 AF546 | 200 µg/ml | $357.00 | |||
MOSC2 Antibody (H-7) Alexa Fluor® 594 | sc-514202 AF594 | 200 µg/ml | $357.00 | |||
MOSC2 Antibody (H-7) Alexa Fluor® 647 | sc-514202 AF647 | 200 µg/ml | $357.00 | |||
MOSC2 Antibody (H-7) Alexa Fluor® 680 | sc-514202 AF680 | 200 µg/ml | $357.00 | |||
MOSC2 Antibody (H-7) Alexa Fluor® 790 | sc-514202 AF790 | 200 µg/ml | $357.00 | |||
MOSC2 (H-7) Neutralizing Peptide | sc-514202 P | 100 µg/0.5 ml | $68.00 |