Mnk1 Antibody (D-2): sc-133246

Mnk1 Antibody (D-2) is a mouse monoclonal IgG2a antibody that detects Mnk1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mnk1, or MAP kinase-interacting serine/threonine kinase 1, plays a crucial role in cellular signaling pathways, particularly in the regulation of protein synthesis and cell proliferation in response to stress signals. Mnk1 is primarily located in the cytoplasm, where Mnk1 interacts with eukaryotic translation initiation factor 4E (eIF4E), a key regulator of mRNA translation. The interaction between Mnk1 and eIF4E is vital for the phosphorylation of eIF4E, which enhances affinity for the mRNA cap structure, thereby promoting the translation of specific mRNAs that are critical for cell survival and growth under stress conditions. The ability of Mnk1 to modulate protein synthesis in response to extracellular signals underscores Mnk1′s importance in various physiological processes, including cell differentiation and response to environmental stressors. Anti-Mnk1 antibody (D-2) is an essential tool for researchers studying these pathways and their implications in diseases such as cancer and neurodegenerative disorders.

The preferred Mnk1 antibody is Mnk1 Antibody (A-4): sc-133107.