MMP-2 Inhibitor II CAS: 869577-51-5
MF: C16H17NO6S2
MW: 383.4
An irreversible inhibitor of MMP-2 through active-site binding.

MMP-2 Inhibitor II (CAS 869577-51-5)

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Application: MMP-2 Inhibitor II is an irreversible inhibitor of MMP-2 through active-site binding
CAS Number: 869577-51-5
Purity: ≥98%
Molecular Weight: 383.4
Molecular Formula: C16H17NO6S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

MMP-2 Inhibitor II is an oxirane analog of SB-3CT, pMS that is reported to be an irreversible inhibitor of MMP-2 through active-site binding. Although reported to be less potent, it has also been shown enhanced selectivity towards MMP-2 than SB-3CT, pMS. MMP-2 Inhibitor II is an inhibitor of MMP-1.


References

1. Ikejiri, M. et al. 2005. J. Biol. Chem. 280(40): 33992-34002. PMID: 16046398
2. Xue, M. et al. 2014. Rheumatology (Oxford). 53(12): 2270-2279. PMID: 24982240

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml).
Storage :
Store at -20° C
Melting Point :
227.51° C (Predicted)
Boiling Point :
~591.7° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Ki Data :
MMP-2: Ki= 2.4 µM; MMP-7: Ki= 379 µM; MMP-1: Ki= 45 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
15940371
SMILES :
CS(=O)(=O)NC1=CC=C(C=C1)OC2=CC=C(C=C2)S(=O)(=O)CC3CO3

Download SDS (MSDS)

Certificate of Analysis

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