MMP-2 Inhibitor II is an oxirane analog of SB-3CT, pMS that is reported to be an irreversible inhibitor of MMP-2 through active-site binding. Although reported to be less potent, it has also been shown enhanced selectivity towards MMP-2 than SB-3CT, pMS. MMP-2 Inhibitor II is an inhibitor of MMP-1.
1. Ikejiri, M. et al. 2005. J. Biol. Chem. 280(40): 33992-34002. PMID: 16046398 2. Xue, M. et al. 2014. Rheumatology (Oxford). 53(12): 2270-2279. PMID: 24982240
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