mitoNEET Antibody (AT1A8): sc-517413

mitoNEET Antibody (AT1A8) is a mouse monoclonal IgG1 kappa light chain antibody that detects mitoNEET protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). anti-mitoNEET antibody (AT1A8) is available as a non-conjugated format. MitoNEET, also known as CISD1 (CDGSH iron sulfur domain 1) or ZCD1, is a 108 amino acid single-pass type II membrane protein primarily localized to mitochondria, where mitoNEET plays a crucial role in cellular energy metabolism. MitoNEET′s localization is significant due to involvement in regulating electron transport capacity and oxidative phosphorylation, processes vital for ATP production in cells. MitoNEET exists as a homodimer and contains a CDGSH-type zinc finger, essential for binding iron as a cofactor. This interaction maintains mitochondrial function and overall cellular health. MitoNEET shows high expression in heart, liver, and skeletal muscle tissues, indicating importance in energy-demanding organs. Various factors modulate mitoNEET expression, including glibenclamide, an anti-diabetic drug that causes down-regulation, and isoproterenol, a synthetic catecholamine that triggers up-regulation, highlighting mitoNEET′s role in metabolic regulation and potential implications in diseases such as cystic fibrosis, where mitoNEET may interact with cystic fibrosis transmembrane conductance regulator (CFTR).

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mitoNEET Antibody (AT1A8) References:

1. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.  |  Wiley, SE., et al. 2007. Proc Natl Acad Sci U S A. 104: 5318-23. PMID: 17376863
2. The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.  |  Wiley, SE., et al. 2007. J Biol Chem. 282: 23745-9. PMID: 17584744
3. Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins.  |  Lin, J., et al. 2007. Proc Natl Acad Sci U S A. 104: 14640-5. PMID: 17766439
4. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone.  |  Paddock, ML., et al. 2007. Proc Natl Acad Sci U S A. 104: 14342-7. PMID: 17766440
5. Crystallographic studies of human MitoNEET.  |  Hou, X., et al. 2007. J Biol Chem. 282: 33242-33246. PMID: 17905743
6. CISD1 codifies a mitochondrial protein upregulated by the CFTR channel.  |  Taminelli, GL., et al. 2008. Biochem Biophys Res Commun. 365: 856-62. PMID: 18047834

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-mitoNEET Antibody (AT1A8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-mitoNEET Antibody (AT1A8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

mitoNEET Antibody (AT1A8) Specifications

Alternate Product Name: mitoNEET

Product Clone Name: AT1A8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 32-108

Epitope Target: mitoNEET

Epitope Species: human

Product Reactivity/Detection: mitoNEET

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 1% glycerol, and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for mitoNEET Antibody (AT1A8): N/A