Mitofilin Antibody (B-10): sc-390706
- Mitofilin Antibody (B-10) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 364-657 mapping within an internal region of Mitofilin of human origin
- recommended for detection of Mitofilin of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Mitofilin Antibody (B-10) for WB applications. This reagent is now offered in a bundle with Mitofilin Antibody (B-10) (see ordering information below).
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Mitofilin Antibody (B-10) is a mouse monoclonal IgG2a antibody that detects Mitofilin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mitofilin, also known as IMMT, HMP, PIG4, or P87/89, is a crucial 758 amino acid inner mitochondrial membrane protein predominantly expressed in heart tissue, where anti-Mitofilin antibody (B-10) plays a vital role in maintaining mitochondrial cristae morphology. Mitofilin exists in three alternatively spliced isoforms, each contributing to the formation and organization of cristae junctions and normal tubular cristae, which are essential for efficient cellular respiration. The structural integrity of the cristae is critical, as Mitofilin provides a large surface area for the electron transport chain and ATP synthesis, thereby influencing overall mitochondrial function and energy production. Given Mitofilin′s significant role in mitochondrial dynamics and cell survival, Mitofilin monoclonal antibody (B-10) serves as an essential tool for researchers studying mitochondrial biology and related pathologies.
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Mitofilin Antibody (B-10) References:
- Transgenic overexpression of mitofilin attenuates diabetes mellitus-associated cardiac and mitochondria dysfunction. | Thapa, D., et al. 2015. J Mol Cell Cardiol. 79: 212-23. PMID: 25463274
- Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure. | Ding, C., et al. 2015. Sci Rep. 5: 16064. PMID: 26530328
- The role of mitofilin in left ventricular hypertrophy in hemodialysis patients. | Wu, QS., et al. 2018. Ren Fail. 40: 252-258. PMID: 29619900
- Mitochondrial inner membrane protein, Mic60/mitofilin in mammalian organ protection. | Feng, Y., et al. 2019. J Cell Physiol. 234: 3383-3393. PMID: 30259514
- Potential Role of Mic60/Mitofilin in Parkinson's Disease. | Van Laar, VS., et al. 2018. Front Neurosci. 12: 898. PMID: 30740041
- Cardiac ischemia/reperfusion stress reduces inner mitochondrial membrane protein (mitofilin) levels during early reperfusion. | Tombo, N., et al. 2020. Free Radic Biol Med. 158: 181-194. PMID: 32726689
- Mitofilin Mitigates Myocardial Damage in Acute Myocardial Infarction by Regulating Pyroptosis of Cardiomyocytes. | Ma, M., et al. 2022. Front Cardiovasc Med. 9: 823591. PMID: 35586659
- RIP3 Translocation into Mitochondria Promotes Mitofilin Degradation to Increase Inflammation and Kidney Injury after Renal Ischemia-Reperfusion. | Feng, Y., et al. 2022. Cells. 11: PMID: 35741025
- Mitofilin Heterozygote Mice Display an Increase in Myocardial Injury and Inflammation after Ischemia/Reperfusion. | Feng, Y., et al. 2023. Antioxidants (Basel). 12: PMID: 37107296
- Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions. | Chaurembo, AI., et al. 2024. Pharmacol Res. 203: 107164. PMID: 38569981
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mitofilin Antibody (B-10) | sc-390706 | 200 µg/ml | $322.00 | |||
Mitofilin Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-552116 | 200 µg Ab; 10 µg BP | $361.00 |