Molecular structure of Minaprine dihydrochloride, CAS Number: 25905-77-5
Minaprine dihydrochloride (CAS 25905-77-5)
Alternate Names:
N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
CAS Number:
25905-77-5
Molecular Weight:
371.30
Molecular Formula:
C17H22N4O•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Minaprine dihydrochloride functions as a reversible inhibitor of monoamine oxidase (MAO). It acts by binding to the active site of the enzyme, preventing the oxidation of monoamine neurotransmitters such as serotonin, dopamine, and norepinephrine. This inhibition leads to an increase in the levels of these neurotransmitters in the synaptic cleft, thereby prolonging their action and enhancing neurotransmission. Its mechanism of action involves the modulation of intracellular signaling pathways and the regulation of gene expression related to cell survival and neuroprotection.
Minaprine dihydrochloride (CAS 25905-77-5) References
- Double-blind, placebo-controlled, fixed dose trial of minaprine in patients with major depression. | Amsterdam, JD., et al. 1989. Pharmacopsychiatry. 22: 137-43. PMID: 2668978
- High-content screening identifies a role for Na(+) channels in insulin production. | Szabat, M., et al. 2015. R Soc Open Sci. 2: 150306. PMID: 27019722
- An Unbiased Drug Screen for Seizure Suppressors in Duplication 15q Syndrome Reveals 5-HT1A and Dopamine Pathway Activation as Potential Therapies. | Roy, B., et al. 2020. Biol Psychiatry. 88: 698-709. PMID: 32507391
- Minaprine and imipramine in the treatment of major depressive disorders. A comparative double-blind study. | Bohacek, N., et al. 1987. Drugs Exp Clin Res. 13: 435-42. PMID: 3308390
- Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminal of hippocampus of rat. | Muramatsu, M., et al. 1988. Neuropharmacology. 27: 603-9. PMID: 3419543
- Induction of turning by direct intrastriatal injection of dopaminomimetic drugs in mice: pharmacological analysis of a simple screening model. | Worms, P., et al. 1986. Life Sci. 39: 2199-208. PMID: 3537602
- Disposition and metabolism of minaprine in the rat. | Caccia, S., et al. 1985. Xenobiotica. 15: 1111-9. PMID: 4090530
- Quantitative analysis of minaprine and some of its metabolites with application to kinetic studies in rats. | Fong, MH., et al. 1983. J Chromatogr. 259: 141-9. PMID: 6853632
- Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug. | Bizière, K., et al. 1982. Arzneimittelforschung. 32: 824-31. PMID: 6890359
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Minaprine dihydrochloride, 1 g | sc-253049 | 1 g | $65.00 |