MIF Antibody (11): sc-130329

MIF Antibody (11) is a mouse monoclonal IgG2a antibody that detects macrophage migration inhibitory factor (MIF) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). MIF is a secreted, homotrimeric pro-inflammatory cytokine that plays a crucial role in modulating macrophage and T cell functions, making anti-MIF antibody (11) an essential tool for studying host immune response to infection. MIF is primarily produced by the pituitary gland and is expressed in various immune cells, including monocytes and macrophages, as well as in differentiating cells in the eye lens and brain. Notably, MIF is found at sites of inflammation, indicating significant involvement in regulating macrophage activity during host defense. Elevated levels of MIF have been associated with severe sepsis and septic shock, where MIF enhances the production of other inflammatory cytokines such as tumor necrosis factor α (TNFα), interleukin-1 (IL-1), and interferon-γ (IFN-γ). Furthermore, MIF′s ability to counteract glucocorticoid-mediated inhibition of immune-cell activation underscores MIF′s role in promoting systemic inflammatory responses. MIF monoclonal antibody (11) serves as an invaluable tool for researchers investigating the complex mechanisms of inflammation and immune regulation, providing insights into potential therapeutic targets for inflammatory diseases.

The preferred MIF antibody is MIF Antibody (D-2): sc-271631.