Molecular structure of Metoprolol succinate, CAS Number: 98418-47-4
Metoprolol succinate (CAS 98418-47-4)
Alternate Names:
butanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol; Toprol XL; Selozok
Application:
Metoprolol succinate is a selective β1 receptor blocker
CAS Number:
98418-47-4
Molecular Weight:
652.82
Molecular Formula:
2(C15H25NO3)•C4H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Metoprolol succinate is a beta-blocking agent that inhibits the effects of epinephrine. This is achieved by binding to beta-adrenergic receptors located on the surface of cells in the heart, blood vessels, and other organs. By obstructing these receptors, metoprolol succinate prevents the binding of epinephrine to them. As a result, the heart rate is slowed, and the force of the heart′s contractions is reduced.
Metoprolol succinate (CAS 98418-47-4) References
- Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity. | Falkner, B., et al. 2006. J Clin Hypertens (Greenwich). 8: 336-43. PMID: 16687942
- Metoprolol succinate therapy associated with erythema multiforme. | Hong, JA. and Bisognano, JD. 2009. Cardiol J. 16: 82-3. PMID: 19130421
- Tablet splitting: Product quality assessment of metoprolol succinate extended release tablets. | Zhao, N., et al. 2010. Int J Pharm. 401: 25-31. PMID: 20849940
- Pulsatile multiparticulate drug delivery system for metoprolol succinate. | Jagdale, SC., et al. 2011. Arch Pharm Res. 34: 369-76. PMID: 21547667
- Bilayer mucoadhesive microparticles for the delivery of metoprolol succinate: Formulation and evaluation. | Kumar, K., et al. 2015. Artif Cells Nanomed Biotechnol. 43: 328-33. PMID: 24579883
- In Silico comparison between metoprolol succinate and bisoprolol on 24-hour systolic blood pressures. | Jansson, SO., et al. 2014. Drugs R D. 14: 325-32. PMID: 25488798
- Marked hypertriglyceridemia in a woman receiving metoprolol succinate. | Kim, Y. and Miller, M. 2014. J Clin Lipidol. 8: 640-643. PMID: 25499948
- Controlled release floating multiparticulates of metoprolol succinate by hot melt extrusion. | Malode, VN., et al. 2015. Int J Pharm. 491: 345-51. PMID: 26142246
- Comparison of metoprolol succinate versus carvedilol in time to cardiovascular admission in a Veterans Affairs healthcare system: An observational study. | Church, KM., et al. 2015. Am J Health Syst Pharm. 72: S183-90. PMID: 26582307
- A new polymorphic form of metoprolol succinate. | Zhou, M., et al. 2017. Pharm Dev Technol. 22: 58-62. PMID: 26906168
- Effect of carvedilol vs metoprolol succinate on mortality in heart failure with reduced ejection fraction. | Ajam, T., et al. 2018. Am Heart J. 199: 1-6. PMID: 29754646
- Extended release delivery system of metoprolol succinate using hot-melt extrusion: effect of release modifier on methacrylic acid copolymer. | Sawant, KP., et al. 2018. Drug Deliv Transl Res. 8: 1679-1693. PMID: 29948916
- Development and Validation of RP-HPLC and an Ecofriendly HPTLC Method for Simultaneous Determination of Felodipine and Metoprolol Succinate, and their Major Metabolites in Human Spiked Plasma. | Emam, AA., et al. 2020. J AOAC Int. 103: 966-971. PMID: 33241342
- Elucidation of the Controlled-Release Behavior of Metoprolol Succinate from Directly Compressed Xanthan Gum/Chitosan Polymers: Computational and Experimental Studies. | Dadou, SM., et al. 2020. ACS Biomater Sci Eng. 6: 21-37. PMID: 33463201
- Chemometric spectrophotometric methods for simultaneous estimation of metoprolol succinate and amlodipine besylate in their tablet formulation. | Kamal, AH., et al. 2021. Spectrochim Acta A Mol Biomol Spectrosc. 254: 119641. PMID: 33711776
Inhibitor of:
beta1-AR, G β1, and MCAD.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Metoprolol succinate, 25 mg | sc-358365 | 25 mg | $96.00 |