MetAP-2 Antibody (D-7): sc-166773

MetAP-2 Antibody (D-7) is a mouse monoclonal IgG1 antibody that detects methionine aminopeptidase 2 (MetAP-2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MetAP-2 plays a crucial role in protein maturation by removing N-terminal methionine residues from nascent peptides, a process essential for proper folding and function of many proteins. MetAP-2 enzymatic activity regulates cell proliferation through various cellular processes that influence growth and differentiation. Neurofibromin (NF1) tightly regulates MetAP-2 expression, and increased MetAP-2 levels have been associated with several types of cancer, making MetAP-2 a significant target for therapeutic intervention. MetAP-2 inhibitors, such as ovalicin and fumagillin, have shown promise in cancer treatment by blocking MetAP-2 activity, thereby potentially hindering tumor proliferation, especially in NF1-associated malignancies. Conservation of MetAP-2 between humans and model organisms like Saccharomyces cerevisiae underscores fundamental biological importance, making anti-MetAP-2 antibody (D-7) an invaluable tool for researchers studying MetAP-2 role in health and disease.

The preferred MetAP-2 antibody is MetAP-2 Antibody (F-7): sc-365637.