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Menaquinone 9 (CAS 523-39-7)

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Alternate Names:
Menaquinone 9 is also known as MK9.
Application:
Menaquinone 9 is a vitamin K2 homolog which acts as a prothrombogenic agent and functional electron transfer component in nitrate reductase.
CAS Number:
523-39-7
Purity:
≥98%
Molecular Weight:
785.23
Molecular Formula:
C56H80O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Menaquinone 9 is a form of vitamin K2 which acts as a prothrombogenic agent. Studies suggest that menaquinones are susceptible to rapid photooxidation at the isoprene unit closest to the quinone ring in the presence of oxygen and light. In addition, Menaquinone 9 is a functional electron transfer component in nitrate reductase. Menaquinone 9 can be detected in samples via UV spectroscopy at 248 nm. It is known that menaquinones act as intermediates accepting 2 electrons from each NADH molecule and transferring them to other molecules for anaerobic respiration in bacteria. Addditionally, vitamin K can be reduced by the enzyme vitamin K epoxide reductase.


Menaquinone 9 (CAS 523-39-7) References

  1. Colonic absorption of menaquinone-4 and menaquinone-9 in rats.  |  Ichihashi, T., et al. 1992. J Nutr. 122: 506-12. PMID: 1542008
  2. Comparative metabolism of phylloquinone and menaquinone-9 in rat liver.  |  Will, BH. and Suttie, JW. 1992. J Nutr. 122: 953-8. PMID: 1552370
  3. Primary photochemistry in the facultatively aerobic green photosynthetic bacterium Chloroflexus aurantiacus.  |  Bruce, BD., et al. 1982. Proc Natl Acad Sci U S A. 79: 6532-6. PMID: 16593246
  4. High dietary menaquinone intake is associated with reduced coronary calcification.  |  Beulens, JW., et al. 2009. Atherosclerosis. 203: 489-93. PMID: 18722618
  5. Geodermatophilus brasiliensis sp. nov., isolated from Brazilian soil.  |  Bertazzo, M., et al. 2014. Int J Syst Evol Microbiol. 64: 2841-2848. PMID: 24871776
  6. Arthrobacter silvisoli sp. nov., isolated from forest soil.  |  Yan, R., et al. 2018. Int J Syst Evol Microbiol. 68: 3892-3896. PMID: 30351271
  7. Amycolatopsis panacis sp. nov., isolated from Panax notoginseng rhizospheric soil.  |  Peng, G., et al. 2019. Int J Syst Evol Microbiol. 69: 567-571. PMID: 30605074
  8. The acid-base and redox properties of menaquinone MK-4, MK-7, and MK-9 (vitamin K2) in DMPC monolayers on mercury.  |  Dharmaraj, K., et al. 2020. Eur Biophys J. 49: 279-288. PMID: 32372117
  9. Arthrobacter mobilis sp. nov., a novel actinobacterium isolated from Cholistan desert soil.  |  Ye, JJ., et al. 2020. Int J Syst Evol Microbiol. 70: 5445-5452. PMID: 32886595
  10. Vitamin K (phylloquinone and menaquinones) in foods - Optimisation of extraction, clean-up and LC-ESI-MS/MS method for quantification.  |  Jensen, MB., et al. 2021. Food Chem. 345: 128835. PMID: 33321348
  11. Aeromicrobium terrae sp. nov., isolated from a maize field.  |  Lin, SY., et al. 2021. Int J Syst Evol Microbiol. 71: PMID: 33400640
  12. Umezawaea beigongshangensis sp. nov., Isolated From the Mash of Baijiu.  |  Ren, Q., et al. 2021. Curr Microbiol. 78: 4127-4131. PMID: 34661700
  13. Luteolibacter marinus sp. nov., a novel bacterium in the family Verrucomicrobiaceae, isolated from marine sediment.  |  Xie, F., et al. 2022. Int J Syst Evol Microbiol. 72: PMID: 36256567
  14. Isolation and identification of menaquinone-9 from purified nitrate reductase of Escherichia coli.  |  Brito, F., et al. 1995. J Bacteriol. 177: 3728-35. PMID: 7601837
  15. Induction of prothrombin synthesis by K-vitamins compared in vitamin K-deficient and in brodifacoum-treated rats.  |  Craciun, AM., et al. 1998. Biochim Biophys Acta. 1380: 75-81. PMID: 9545541

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Menaquinone 9, 10 mg

sc-211788
10 mg
$310.00

how to identify menaquinone-9 as a product in enzymatic reaction?

Asked by: sasaini
Thank you for your question. Please contact our technical service department by phone or email. (800)-457-3801 or scbt@scbt.com
Answered by: BlakeJ
Date published: 2022-11-14

Has an extinction coefficient been established in the literature for MK9?

Asked by: jeffrey581
Thank you for your question. Unfortunately this data is not available.
Answered by: Technical Support
Date published: 2020-07-07

What is the solubility of the compound?

Asked by: two2igm05
Thank you for your question. Menaquinone 9, sc-211788, is slightly soluble in benzene, chloroform and ethyl acetate.
Answered by: Chemical Support 4
Date published: 2017-08-23

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This chemical, Menaquinone 9: sc-211788, has a yellow crystal powder appearance.
Answered by: Chemical Support 3
Date published: 2017-01-31
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Rated 5 out of 5 by from BritoBrito, F. et al. (PubMed 7601837) reported the first isolation and identification of Menaquinone 9, a prothrombogenic agent, from purified nitrate reductase of Escherichia coli. -SCBT Publication Review
Date published: 2015-03-07
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Menaquinone 9 is rated 5.0 out of 5 by 1.
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