MDGI Antibody (G-4): sc-514208

MDGI Antibody (G-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects MDGI protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MDGI (G-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MDGI protein, also known as Fatty Acid Binding Protein 3, plays a crucial role in lipid metabolism, particularly in heart and skeletal muscle, where MDGI facilitates uptake and transport of fatty acids. This function helps maintain energy homeostasis and supports cellular metabolism, especially during periods of increased energy demand, such as exercise or stress. MDGI is predominantly expressed in myocardium and muscle fibers, as well as in lipid and steroid-synthesizing cells, highlighting MDGI′s importance in both energy production and regulation of lipid storage. MDGI′s ability to bind and transport fatty acids effectively underscores MDGI′s significance in metabolic processes and potential implications in metabolic disorders, making anti-MDGI antibody (G-4) an essential tool for researchers studying lipid metabolism and related diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MDGI Antibody (G-4) References:

1. The fatty acid transport function of fatty acid-binding proteins.  |  Storch, J. and Thumser, AE. 2000. Biochim Biophys Acta. 1486: 28-44. PMID: 10856711
2. Unravelling the significance of cellular fatty acid-binding proteins.  |  Glatz, JF. and Storch, J. 2001. Curr Opin Lipidol. 12: 267-74. PMID: 11353329
3. Fatty acid-binding proteins of nervous tissue.  |  Veerkamp, JH. and Zimmerman, AW. 2001. J Mol Neurosci. 16: 133-42; discussion 151-7. PMID: 11478368
4. Circulating concentrations of cardiac proteins in complicated and uncomplicated Plasmodium falciparum malaria.  |  Ehrhardt, S., et al. 2004. Trop Med Int Health. 9: 1099-103. PMID: 15482402
5. α-Lipoic acid ameliorates mitochondrial impairment and reverses apoptosis in FABP3-overexpressing embryonic cancer cells.  |  Zhou, L., et al. 2013. J Bioenerg Biomembr. 45: 459-66. PMID: 23536161
6. Hydrodynamic and circular dichroic analysis of mammary-derived growth inhibitor (MDGI).  |  Behlke, J., et al. 1989. Biochem Biophys Res Commun. 161: 363-70. PMID: 2730664
7. miR-192-5p mediates hypoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes via targeting of FABP3.  |  Zhang, Y., et al. 2017. J Biochem Mol Toxicol. 31: PMID: 27780314
8. Fatty acid binding to the human transport proteins FABP3, FABP4, and FABP5 from a Ligand's perspective.  |  Michler, S., et al. 2024. J Biol Chem. 300: 107396. PMID: 38777142
9. HH2A, an immortalized bovine mammary epithelial cell line, expresses the gene encoding mammary derived growth inhibitor (MDGI).  |  Huynh, H. and Pollak, M. 1995. In Vitro Cell Dev Biol Anim. 31: 25-9. PMID: 7535635
10. Histochemical localization of heart-type fatty-acid binding protein in human and murine tissues.  |  Zschiesche, W., et al. 1995. Histochem Cell Biol. 103: 147-56. PMID: 7634154
11. Cytoplasmic fatty acid-binding proteins: their structure and genes.  |  Veerkamp, JH. and Maatman, RG. 1995. Prog Lipid Res. 34: 17-52. PMID: 7644552
12. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.  |  Hotamisligil, GS., et al. 1996. Science. 274: 1377-9. PMID: 8910278

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MDGI Antibody (G-4) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-MDGI Antibody (G-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MDGI Antibody (G-4) Specifications

Alternate Product Name: FABP3

Product Clone Name: G-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 21-38

Epitope Target: MDGI

Epitope Species: human

Product Reactivity/Detection: MDGI

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for MDGI Antibody (G-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred B-FABP antibody is B-FABP Antibody (F-6): sc-374588.