MDGI Antibody (66E2): sc-58274
- MDGI Antibody (66E2) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- raised against native full length MDGI of human origin
- recommended for detection of MDGI of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with I-FABP or L-FABP of human origin
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MDGI Antibody (66E2) for WB applications. This reagent is now offered in a bundle with MDGI Antibody (66E2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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MDGI Antibody (66E2) is a mouse monoclonal IgG1 antibody that detects MDGI in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Mammary-derived growth inhibitor (MDGI), also known as Fatty Acid-Binding Protein 3 (FABP3), plays a crucial role in the transport and metabolism of fatty acids, which are essential for energy production and cellular function. Anti-MDGI antibody (66E2) recognizes a protein predominantly expressed in the myocardium, skeletal and smooth muscle fibers, as well as in lipid and steroid synthesizing cells, highlighting its importance in maintaining metabolic homeostasis. The ability of MDGI to bind and transport fatty acids is vital for cellular energy balance, particularly in tissues with high metabolic demands, such as the heart and skeletal muscles. Furthermore, MDGI is involved in various physiological processes, including the regulation of lipid metabolism and the modulation of inflammatory responses, making MDGI (66E2) antibody an important tool for research in metabolic disorders and cardiovascular diseases.
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MDGI Antibody (66E2) References:
- Purification of a mammary-derived growth inhibitor (MDGI) related polypeptide expressed during pregnancy. | Brandt, R. and Grosse, R. 1992. Biochem Biophys Res Commun. 189: 406-13. PMID: 1280424
- Differentiation-promoting effects of mammary-derived growth inhibitor (MDGI) on pluripotent mouse embryonic stem cells. | Wobus, AM., et al. 1990. Virchows Arch B Cell Pathol Incl Mol Pathol. 59: 339-42. PMID: 1981402
- Silencing of FABP3 inhibits proliferation and promotes apoptosis in embryonic carcinoma cells. | Shen, Y., et al. 2013. Cell Biochem Biophys. 66: 139-46. PMID: 23097025
- FABP3 protein promotes α-synuclein oligomerization associated with 1-methyl-1,2,3,6-tetrahydropiridine-induced neurotoxicity. | Shioda, N., et al. 2014. J Biol Chem. 289: 18957-65. PMID: 24855640
- A mammary-derived growth inhibitor (MDGI) related 70 kDa antigen identified in nuclei of mammary epithelial cells. | Müller, T., et al. 1989. J Cell Physiol. 138: 415-23. PMID: 2918043
- Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization. | Cheng, A., et al. 2019. Brain Res. 1707: 190-197. PMID: 30496735
- Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice. | Matsuo, K., et al. 2021. Brain Res. 1760: 147383. PMID: 33636166
- FABP3, FABP4, and heart rate variability among patients with chronic schizophrenia. | Hung, WC., et al. 2023. Front Endocrinol (Lausanne). 14: 1165621. PMID: 37255976
- The human mammary-derived growth inhibitor (MDGI) gene: genomic structure and mutation analysis in human breast tumors. | Phelan, CM., et al. 1996. Genomics. 34: 63-8. PMID: 8661024
- Silencing of the mammary-derived growth inhibitor (MDGI) gene in breast neoplasms is associated with epigenetic changes. | Huynh, H., et al. 1996. Cancer Res. 56: 4865-70. PMID: 8895735
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDGI Antibody (66E2) | sc-58274 | 200 µg/ml | $322.00 | |||
MDGI Antibody (66E2): m-IgGκ BP-HRP Bundle | sc-521052 | 200 µg Ab, 40 µg BP | $361.00 |