MALP-2
See product citations (3)
Alternate Names:
Macrophage-activating lipopeptide-2; S-[2,3-bis(Palmityloxy)-(2R)-propyl-cysteinyl-GNNDESNISFKEK]
Application:
MALP-2 is a TLR activator
Molecular Weight:
2135.55
Molecular Formula:
C99H167N19O30S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
MALP-2 is isolated from Mycoplasma fermentans which corresponds to the originally isolated isomer. MALP-2 expresses potent endotoxin-like activity and approaches in certain experimental systems the toxicity of LPS. Signalling, unlike that of LPS, is not transduced via TLR4, but is induced via TLR2 and TLR6 signalling. Specific activity is ~2x108units/mg. One unit of MALP-2 is defined as the dilution giving half maximal release of nitric oxide from C3H/HeJ mouse peritoneal exudate cells in the standard assay.
MALP-2 References
- Effect of MALP-2, a lipopeptide from Mycoplasma fermentans, on bone resorption in vitro. | Piec, G., et al. 1999. Infect Immun. 67: 6281-5. PMID: 10569738
- Site-specific proteolysis of the MALP-404 lipoprotein determines the release of a soluble selective lipoprotein-associated motif-containing fragment and alteration of the surface phenotype of Mycoplasma fermentans. | Davis, KL. and Wise, KS. 2002. Infect Immun. 70: 1129-35. PMID: 11854192
- Synergic effects of mycoplasmal lipopeptides and extracellular ATP on activation of macrophages. | Into, T., et al. 2002. Infect Immun. 70: 3586-91. PMID: 12065499
- MALP-2 pre-treatment modulates systemic inflammation in hemorrhagic shock. | Pfeifer, R., et al. 2013. J Inflamm (Lond). 10: 17. PMID: 23587413
- Locally applied macrophage-activating lipopeptide-2 (MALP-2) promotes early vascularization of implanted porous polyethylene (Medpor®). | Laschke, MW., et al. 2014. Acta Biomater. 10: 4661-4669. PMID: 25062995
- Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection. | Reppe, K., et al. 2015. Infect Immun. 83: 4617-29. PMID: 26371127
- Effects of macrophage-activating lipopeptide-2 (MALP-2) on the vascularisation of implanted polyurethane scaffolds seeded with microvascular fragments. | Grässer, C., et al. 2016. Eur Cell Mater. 32: 74-86. PMID: 27386841
- The Lipopeptide MALP-2 Promotes Collateral Growth. | Troidl, K., et al. 2020. Cells. 9: PMID: 32316253
- The Influence of Macrophage-Activating Lipopeptide 2 (MALP-2) on Local and Systemic Inflammatory Response in a Murine Two-Hit Model of Hemorrhagic Shock and Subsequent Sepsis. | Xu, D., et al. 2021. Inflammation. 44: 481-492. PMID: 33420893
- Macrophage-activating lipoprotein (MALP)-2 impairs the healing of partial tendon injuries in mice. | Fritz, T., et al. 2022. Ann Anat. 239: 151818. PMID: 34391911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MALP-2, 50 µg | sc-221869 | 50 µg | $423.00 |