Molecular structure of Lumefantrine, CAS Number: 82186-77-4
Lumefantrine (CAS 82186-77-4)
See product citations (2)
Alternate Names:
Benflumetol, CPG-56695
Application:
Lumefantrine is an antimalarial which inhibits hemozoin formation
CAS Number:
82186-77-4
Molecular Weight:
528.94
Molecular Formula:
C30H32Cl3NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Lumefantrine is a compound that is extensively studied in the field of parasitology, particularly for its role in the inhibition of heme polymerization within the malaria parasite, Plasmodium falciparum. Researchers utilize lumefantrine in investigations to understand its mode of action and the molecular basis of its interaction with the malarial parasite. It is also a subject in studies aimed at elucidating the mechanisms of chemical resistance that the malaria parasite develops. Moreover, the compound is used in mechanistic and kinetics studies to determine its behavior within biological systems, including absorption, distribution, metabolism, and excretion profiles.
Lumefantrine (CAS 82186-77-4) References
- The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria. | Chotivanich, K., et al. 2000. J Infect Dis. 182: 629-33. PMID: 10915102
- Artemether-lumefantrine for treating uncomplicated falciparum malaria. | Omari, AA., et al. 2002. Cochrane Database Syst Rev. CD003125. PMID: 12137676
- Artemether-lumefantrine for treating uncomplicated falciparum malaria. | Omari, AA., et al. 2003. Cochrane Database Syst Rev. CD003125. PMID: 12804451
- Artemether-lumefantrine for uncomplicated malaria: a systematic review. | Omari, AA., et al. 2004. Trop Med Int Health. 9: 192-9. PMID: 15040555
- Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial. | Mutabingwa, TK., et al. Lancet. 365: 1474-80. PMID: 15850631
- Artemether-lumefantrine (six-dose regimen) for treating uncomplicated falciparum malaria. | Omari, AA., et al. 2005. Cochrane Database Syst Rev. 2005: CD005564. PMID: 16235412
- WITHDRAWN: Artemether-lumefantrine for treating uncomplicated falciparum malaria. | Omari, AA., et al. 2007. Cochrane Database Syst Rev. 2003: CD003125. PMID: 17636715
- Artemether-lumefantrine: an oral antimalarial for uncomplicated malaria in children. | Adjei, GO., et al. 2009. Expert Rev Anti Infect Ther. 7: 669-81. PMID: 19681693
- The clinical efficacy of artemether/lumefantrine (Coartem). | Makanga, M. and Krudsood, S. 2009. Malar J. 8 Suppl 1: S5. PMID: 19818172
- Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum. | Kumar, N. and Zheng, H. 1990. Parasitol Res. 76: 214-8. PMID: 2179946
- Artemether-lumefantrine: an option for malaria. | Stover, KR., et al. 2012. Ann Pharmacother. 46: 567-77. PMID: 22496476
- Quantitative determination of the antimalarials artemether and lumefantrine in biological samples: A review. | Resende, LA., et al. 2019. J Pharm Biomed Anal. 165: 304-314. PMID: 30579231
- Co-precipitates of lumefantrine-Eudragit E PO for dissolution improvement. | Patel, R. and Wairkar, S. 2022. Ann Pharm Fr. 80: 59-66. PMID: 34033746
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lumefantrine, 5 mg | sc-207836 | 5 mg | $122.00 |