liver FBPase Antibody (B-11): sc-376388

Liver FBPase Antibody (B-11) is a mouse monoclonal IgG1 antibody that detects liver FBPase in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Liver FBPase, a crucial enzyme in carbohydrate metabolism, catalyzes the conversion of fructose-1,6-bisphosphate into fructose 6-phosphate and inorganic phosphate, thereby playing a vital role in gluconeogenesis and maintaining blood glucose levels. The enzyme is encoded by the FBP1 gene and is primarily expressed in the liver, where FBP1 exists as a tetramer composed of four identical subunits. This structural arrangement is essential for enzymatic activity and regulation, as FBP1 allows for cooperative binding of substrates and effective response to metabolic signals. Notably, mutations in the FBP1 gene can lead to a deficiency in liver FBPase, resulting in serious metabolic disorders such as hypoglycemia and metabolic acidosis, underscoring the importance of this protein in human health. Anti-liver FBPase antibody (B-11) is an invaluable tool for researchers studying carbohydrate metabolism and related metabolic disorders.

The preferred FBPase antibody is FBPase Antibody (C-10): sc-166145.