Linoleoyl glycine (CAS 2764-03-6)
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Linoleoyl glycine is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian skin, spinal cord and brain, is a structural counterpart of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. Linoleoyl glycine inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes (IC50 ~ 25 µM), which is less potent than that of arachidonyl glycine (IC50 = 7 µM). The biological significance of linoleoyl glycine has not yet been determined.
Linoleoyl glycine (CAS 2764-03-6) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Linoleoyl glycine, 5 mg | sc-205377 | 5 mg | $89.00 | |||
Linoleoyl glycine, 50 mg | sc-205377A | 50 mg | $714.00 |