LIN-9 Antibody (Mab#1): sc-130571

LIN-9 Antibody (Mab#1) is a mouse monoclonal IgG1 antibody that detects LIN-9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). LIN-9, also known as TGS, BARA, or TGS1, is a 542 amino acid protein that plays a crucial role in regulating the cell cycle by functioning as a component of the DREAM complex, which is essential for the repression of cell cycle-dependent genes. Anti-LIN-9 antibody (Mab#1) recognizes a protein that is vital for maintaining proper cellular function and preventing uncontrolled cell proliferation, making LIN-9 an important tumor suppressor. LIN-9 is primarily localized in the nucleoplasm and is expressed in tissues such as the testis and thymus, where LIN-9 associates with the retinoblastoma protein (Rb) to inhibit DNA synthesis and regulate the expression of genes necessary for the G1/S transition of the cell cycle. Notably, LIN-9 exists in three isoforms due to alternative splicing, which may contribute to its functional diversity. The gene encoding LIN-9 is located on human chromosome 1, a region that spans 260 million base pairs and contains over 3,000 genes, highlighting its significance within the human genome. LIN-9 monoclonal antibody (Mab#1) is an invaluable tool for researchers studying cell cycle regulation and tumor biology.

The preferred LIN-9 antibody is LIN-9 Antibody (C-10): sc-398234.