Lck Inhibitor II (CAS 918870-43-6)
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Lck Inhibitor II is a tri-substituted pyrimidine that is cell-permeable and selectively targets the ATP-binding site of the Lck protein, a critical enzyme in the Src family of tyrosine kinases, achieving high potency (IC50 = 3 nM with ATP concentration at 10 μM). This compound is instrumental in the scientific investigation of Lck′s role in cellular signaling, particularly within the immune system, aiding in the understanding of T-cell activation, differentiation, and function. As a kinase inhibitor, it binds to the Lck protein′s ATP-binding pocket, blocking the phosphorylation of key tyrosine residues in downstream signaling molecules. This action disrupts T-cell receptor signaling pathways, offering insights for research related to immune response mechanisms and the molecular underpinnings of immune-related diseases.
Lck Inhibitor II (CAS 918870-43-6) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lck Inhibitor II, 5 mg | sc-311371 | 5 mg | $454.00 |