Latexin Antibody (8H5): sc-517052

Latexin Antibody (8H5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Latexin protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Latexin antibody (8H5) is available as a non-conjugated antibody and is crucial for studying the role of Latexin, also known as endogenous carboxypeptidase inhibitor (ECI) or tissue carboxypeptidase inhibitor (TCI), which belongs to the protease inhibitor I47 family of proteins. Latexin functions as a non-competitive, reversible inhibitor of metallocarboxypeptidases (MCPs), including CPA1, CPA2, and CPA4, making Latexin significant in regulating proteolytic activity in various physiological processes. Latexin is predominantly located in the cytoplasm and is highly expressed in tissues such as the heart, prostate, pancreas, ovary, kidney, brain, and colon, highlighting Latexin′s importance in diverse biological functions. The structure of Latexin consists of two topologically equivalent subdomains that exhibit low specificity in binding to MCPs, providing flexibility to inhibit all vertebrate A/B MCPs. This structural characteristic allows Latexin to modulate the activity of multiple enzymes, thereby influencing pain transmission and playing a role in inflammatory responses.

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Latexin Antibody (8H5) References:

1. Latexin, a carboxypeptidase A inhibitor, is expressed in rat peritoneal mast cells and is associated with granular structures distinct from secretory granules and lysosomes.  |  Uratani, Y., et al. 2000. Biochem J. 346 Pt 3: 817-26. PMID: 10698712
2. Cloning, tissue expression pattern and genomic organization of latexin, a human homologue of rat carboxypeptidase A inhibitor.  |  Liu, Q., et al. 2000. Mol Biol Rep. 27: 241-6. PMID: 11455960
3. In vitro clonal analysis of rat cerebral cortical neurons expressing latexin, a subtype-specific molecular marker of glutamatergic neurons.  |  Takiguchi-Hayashi, K. 2001. Brain Res Dev Brain Res. 132: 87-90. PMID: 11744110
4. An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1.  |  Aagaard, A., et al. 2005. Structure. 13: 309-17. PMID: 15698574
5. Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin.  |  Pallarès, I., et al. 2005. Proc Natl Acad Sci U S A. 102: 3978-83. PMID: 15738388
6. Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin.  |  García-Castellanos, R., et al. 2005. Cell Mol Life Sci. 62: 1996-2014. PMID: 16091843
7. Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases.  |  Jin, M., et al. 2006. Brain Res. 1075: 117-21. PMID: 16469302

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Latexin Antibody (8H5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Latexin Antibody (8H5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Latexin Antibody (8H5) Specifications

Alternate Product Name: Latexin

Product Clone Name: 8H5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 151-222

Epitope Target: Latexin

Epitope Species: human

Product Reactivity/Detection: Latexin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Latexin Antibody (8H5): N/A