Lariatin A (CAS 732286-09-8)

Lariatin A is a natural cyclic depsipeptide isolated from marine-derived Streptomyces sp. It exhibits potent antifungal activity against a range of fungal pathogens, including Candida albicans and Aspergillus fumigatus. The mechanism of action of lariatin A involves disrupting fungal cell membrane integrity by forming pores, leading to leakage of intracellular contents and ultimately causing fungal cell death. In research, lariatin A has been investigated for its antifungal properties and its potential as a lead compound for the development of new antifungal agents. Researchers have explored the structure-activity relationships of lariatin A analogs to enhance its antifungal efficacy and selectivity. Furthermore, lariatin A has been utilized as a tool in molecular biology and microbiology studies to explain the mechanisms underlying fungal membrane permeabilization and to investigate the molecular targets of lariatin A within fungal cells. Overall, lariatin A holds promise as a valuable research tool for studying fungal biology and developing novel strategies to combat fungal infections, particularly those caused by drug-resistant fungal strains.