LANPL Antibody (C-1): sc-514662

LANPL Antibody (C-1) is a mouse monoclonal IgM kappa light chain antibody that detects LANPL protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LANPL antibody (C-1) is available as the non-conjugated form. LANPL protein, also known as leucine-rich acidic nuclear protein-like or ANP32E, plays a crucial role in cellular signaling pathways and is involved in the regulation of various cellular processes. LANPL primarily localizes in the cytoplasm of peripheral blood leukocytes and various tissues, including the colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver, and kidney, with additional presence in the nucleus and membrane of multiple brain regions. Such localization enables LANPL to interact with key signaling molecules, thereby influencing the dynamics of the cytoskeleton, cell adhesion, and neural development. Upon phosphorylation, LANPL colocalizes with and inhibits protein phosphatase 2A (PP2A), a critical regulator of numerous cellular functions, while not affecting protein phosphatase 1 (PP1). This selective inhibition underscores LANPL′s importance in modulating cellular responses and maintaining proper cellular architecture, making LANPL a vital protein for understanding various physiological and pathological processes.

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LANPL Antibody (C-1) References:

1. Characterization of the nuclear transport of a novel leucine-rich acidic nuclear protein-like protein.  |  Matsubae, M., et al. 2000. FEBS Lett. 468: 171-5. PMID: 10692581
2. Differential expression of CPD1 during postnatal development in the mouse cerebellum.  |  Radrizzani, M., et al. 2001. Brain Res. 907: 162-74. PMID: 11430900
3. Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain.  |  Jiang, M., et al. 2002. Cytogenet Genome Res. 97: 68-71. PMID: 12438741
4. Anp32e (Cpd1) and related protein phosphatase 2 inhibitors.  |  Santa-Coloma, TA. 2003. Cerebellum. 2: 310-20. PMID: 14964690
5. The Anp32 family of proteins containing leucine-rich repeats.  |  Matilla, A. and Radrizzani, M. 2005. Cerebellum. 4: 7-18. PMID: 15895553
6. Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis.  |  Costanzo, RV., et al. 2006. Eur J Neurosci. 23: 309-24. PMID: 16420440
7. NMR assignment of the leucine-rich repeat domain of LANP/Anp32a.  |  de Chiara, C., et al. 2007. J Biomol NMR. 38: 177. PMID: 17180445

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LANPL Antibody (C-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-LANPL Antibody (C-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LANPL Antibody (C-1) Specifications

Alternate Product Name: LANPL

Product Clone Name: C-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 46-68

Epitope Target: LANPL

Epitope Species: human

Product Reactivity/Detection: LANPL

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for LANPL Antibody (C-1): P: Blocking Peptide