LAMP-2 Antibody (5K54): sc-71490
- LAMP-2 Antibody (5K54) is a rat monoclonal IgG2a provided at 200 µg/ml
- raised against glycoprotein fractions purified from BALB/c mouse embryo 3T3 cell line
- recommended for detection of LAMP-2 of mouse origin by WB, IP, IF and FCM
- See LAMP-2 (ABL-93): sc-20004 for LAMP-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LAMP-2 Antibody (5K54). This work is in progress.
LAMP-2 Antibody (5K54) is a rat monoclonal IgG2a antibody raised against glycoprotein fractions purified from the BALB/c mouse embryo 3T3 cell line, with species reactivity in mouse. LAMP-2 monoclonal antibody (5K54) is validated for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). LAMP-2, also known as CD107B, is a glycosylated type I transmembrane protein predominantly localized to the lysosomal membrane. Extensive glycosylation stabilizes LAMP-2, protects the lysosomal membrane from hydrolytic enzymes, and facilitates autophagy by mediating the fusion of autophagosomes with lysosomes. LAMP-2 is synthesized in the endoplasmic reticulum, undergoes glycosylation in the Golgi apparatus, and travels to lysosomes via a pathway distinct from clathrin-coated vesicles. Dysregulation of LAMP-2 expression or modifications has been implicated in lysosomal storage disorders such as Danon disease, highlighting LAMP-2′s importance in lysosomal function and cellular homeostasis. Altered LAMP-2 activity has been linked to tumor invasion and metastasis due to roles in cellular adhesion and proteolytic activity. Anti-LAMP-2 antibody (5K54) serves as an essential tool for exploring post-translational modifications and biological functions of LAMP-2 in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LAMP-2 Antibody (5K54) | sc-71490 | 200 µg/ml | $322.00 |